Polyphenols in Alcoholic Beverages Activating Constitutive Androstane Receptor CAR
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概要
- 論文の詳細を見る
The constitutive androstane receptor CAR is a xenosensing nuclear receptor that can be activated by natural polyphenols such as flavonoids and catechins. We examined alcoholic beverage phytochemicals for their ability to activate CAR. HepG2 cells were transfected with CAR expression vector and its reporter gene, and then treated with trans-resveratrol, ellagic acid, β-caryophyllene, myrcene, and xanthohumol. A luciferase assay revealed that ellagic acid and trans-resveratrol activated both human and mouse CAR. Since CAR regulates many genes involved in energy metabolism, the possibility exists that these polyphenols would reduce the risk of certain alcohol-induced metabolic disorders with the help of CAR.
著者
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Misaka Takumi
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Abe Keiko
Department Of Cardiovascular Physiology And Medicine Graduate School Of Biomedical Sciences Hiroshim
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Kamei Asuka
Kanagawa Acad. Of Sci. And Technol.
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Tsuruoka Nobuo
Institute For Health Care Science Suntory Limited
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Kitagawa Yoshinori
Institute For Health Care Science Suntory Wellness Limited
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Rogi Tomohiro
Institute for Health Care Science, Suntory Wellness Limited, Japan
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YAO Ruiqing
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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YASUOKA Akihito
Department of Biological Engineering, Maebashi Institute of Technology
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TAIEISHI Norifumi
Institute for Health Care Science, Suntory Wellness Ltd.
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KISO Yoshionobu
Institute for Health Care Science, Suntory Wellness Ltd.
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