Influence of Lactobacillus pentosus S-PT84 Ingestion on the Mucosal Immunity of Healthy and Salmonella Typhimurium-Infected Mice
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概要
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Lactobacillus pentosus (L. pentosus) strain S-PT84, isolated from Kyoto pickles, enhances splenic natural killer (NK) cell activity, and has high T-helper1 (Th1) cytokine and type 1-IFN (IFN-α) inducing activity. In the present study, we investigated the influence of S-PT84 ingestion on the mucosal immunity of healthy and Salmonella Typhimurium (S. Typhimurium)-infected mice. In the S. Typhimurium infection model, numbers of S. Typhimurium in feces and the spleen were significantly decreased, and body weight loss and deterioration in the general health score of S. Typhimurium-infected mice were improved by S-PT84 ingestion. Oral administration of S-PT84 enhanced IL-5 and IL-6 production from Peyers patch cells in vitro, with a concomitant significant increase in IgA production from Peyers patch cells, which may explain the mechanism of enhanced IgA production in the small intestine in vivo. These results suggest that S-PT84 ingestion is useful for the maintenance of health or the improvement of certain symptoms during pathogen infection.
- 2011-04-01
著者
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Shibata Hiroko
Laboratory Of Pharmaceutical Proteomics National Institute Of Biomedical Innovation (nibio)
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Shibata Hiroko
医薬基盤研究所 創薬プロテオミクスプロジェクト
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SHIBATA Hiroshi
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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Kiso Yoshinobu
Laboratory For Health Care Science Research Center Suntory Ltd.
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Kiso Yoshinobu
Institute For Biomedical Research Suntory Ltd.
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Kiso Yoshinobu
Suntory Ltd. Osaka Jpn
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Shibata Hiroshi
Laboratory For Health Care Science Research Center Suntory Ltd.
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Shibata H
Laboratory For Health Care Science Research Center Suntory Ltd.
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Kajimoto Yoshinaga
Institute For Health Care Science Suntory Ltd.
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Izumo Takayuki
Institute For Health Care Science Suntory Wellness Limited
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Kiso Yoshinobu
Institute For Health Care Science Suntory Wellness Limited
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Kitagawa Yoshinori
Institute For Health Care Science Suntory Wellness Limited
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Nakagawa Ichiro
Section Of Bacterial Infection Tokyo Medical And Dental University Graduate School Of Medical And De
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IZUMI Fumi
Institute of Health Care Science, Suntory Wellness Limited
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Izumi Fumi
Institute Of Health Care Science Suntory Wellness Limited
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Saito Hiroyuki
Third Department Of Internal Medicine Asahikawa Medical College
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Shibata Hiroshi
Institute Of Health Care Science Suntory Wellness Limited
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Shibata Hiroshi
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.:department Of Animal Scienc
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SHIBATA Hiroshi
Institute for Biomedical Research, Suntory Limited
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