Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VI. Inhibitory Effects of Caffeoylquinic Acids on Histamine Release from Rat Peritoneal Mast Cells
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概要
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The inhibitory effects of caffeoylquinic acids isolated from the leaves of Artemisia species on the histamine release from rat mast cells induced by compound 48/80,and on that induced by concanavalin A plus phosphatidylserine were determined. At the concentration of 2.5×10^<-5>M, caffeic acid, chlorogenic acid and methyl chlorogenate exhibited over 50% inhibition of the histamine secretion induced by compound 48/80 from mast cells. The inhibitory effects of caffeic acid and monocaffeoylquinic acids (chlorogenic acid and methyl chlorogenate) were higher than those of dicaffeoylquinic acids on the compound 48/80-induced histamine release from mast cells. On the other hand, caffeic acid, chlorogenic acid and 3,5-di-O-caffeoylquinic acid exhibited over 50% inhibition of the histamine secretion induced by concanavalin A plus phosphatidylserine from mast cells at the concentration of 10^<-5>M.
- 公益社団法人日本薬学会の論文
- 1985-02-25
著者
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奥田 拓男
Faculty of Pharmaceutical Sciences, Okayama University
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波多野 力
Faculty of Pharmaceutical Sciences, Okayama University
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木村 善行
愛媛大学大学院医学系研究科統合医科学講座薬理生化学分野
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縣 功
Faculty of Pharmacy, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto.
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奥村 智子
Faculty Of Pharmaceutical Sciences Okayama University
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有地 滋
The Research Institute of Oriental Medicine, Kinki University
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有地 滋
The Research Institute Of Oriental Medicine Kinki University
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有地 滋
近畿大学東洋医学研究所
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奥田 拓道
愛媛大学
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奥田 拓道
熊本県立大学環境共生学部環境共生学科食健康環境学科
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奥田 拓道
2nd Department of Medical Biochemistry, School of Medicine, Ehime University
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Kiso Yoshinobu
Institute For Biomedical Research Suntory Ltd.
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奥田 拓男
Faculty Of Parmaceutical Sciences University
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木村 善行
2nd Department of Medical Biochemistry, School of Medicine, Ehime University
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有地 滋
愛媛大学
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縣 功
Faculty Of Pharmaceutical Sciences Higashi Nippon Gakuen University
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