Effects of Interaction of Tannins with Co-existing Substances. VII. : Inhibitory Effects of Tannins and Related Polyphenols on Xanthine Oxidase
スポンサーリンク
概要
- 論文の詳細を見る
The inhibitory effects of hydrolyzable tannins, condensed tannins and related polyphenols on the activity of xanthine oxidase (XOD), catalyzing uric acid formation from xanthine, were investigated. Marked differences in the strength of the inhibition were observed. Some of the differences among the monomeric hydrolyzable tannins were due to their molecular weights, reflecting the number of phenolic hydroxyl groups in the molecule. However, the inhibitory activity of several oligomaric hydrolyzable tannins seemed particularly low in spite of their large molecular size. It was also observed that differences in location of acyl groups on the carbohydrate cores caused differences in the inhibitory activity among monomeric and oligomeric hydrolyzable tannins. A caffeic acid derivative (caffeetannin), 3,5-di-O-caffeoylquinic acid (24), also inhibited this enzyme. Galloylation and the degree of polymerization in proanthocyanidins were also shown to affect remarkably the strength of the inhibition. Among the compounds tested in the present study, valoneic acid dilactone (29), isolated from Mallotus japonicus, inhibited the enzyme most effectively. A kinetic study showed that this dilactone inhibited XOD non-competitively. Comparison of the inhibitory effect on XOD, with the binding activity to hemoglobin, for each tannin, suggests that their inhibition of XOD is not based on non-specific binding to the protein. Similar comparison of the inhibitory effect on XOD with the inhibitory effect on the generation of superoxide anion radical (O_2^-) from the hypoxanthine-XOD system revealed that the inhibition of O_2^- generation by tannins is due to their radical-scavenging activity, and not due to their inhibitory activity upon the enzyme.
- 公益社団法人日本薬学会の論文
- 1990-05-25
著者
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奥田 拓男
Faculty of Pharmaceutical Sciences, Okayama University
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波多野 力
Faculty of Pharmaceutical Sciences, Okayama University
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Hatano Tsutomu
エジプト
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縣 功
Faculty of Pharmacy, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto.
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野呂 忠敬
静岡県立大学
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奥村 智子
Faculty Of Pharmaceutical Sciences Okayama University
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Hatano Tsutomu
Department Of Pharmacognosy Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti
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安原 多恵子
Faculty of Pharmaceutical Sciences, Okayama University
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奥田 拓男
Faculty Of Parmaceutical Sciences University
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野呂 忠敬
School of Pharmaceutical Sciences, University of Shizuoka
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吉原 里栄子
Faculty of Pharmaceutical Sciences, Okayama University
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縣 功
Faculty Of Pharmaceutical Sciences Higashi Nippon Gakuen University
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野呂 忠敬
School Of Pharmaceutical Sciences University Of Shizuoka
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吉原 里栄子
Faculty Of Pharmaceutical Sciences Okayama University
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安原 多恵子
Faculty Of Pharmaceutical Sciences Okayama University
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