Effects of the Interaction of Tannins with Co-existing Substances. VI. : Effects of Tannins and Related Polyphenols on Superoxide Anion Radical, and on 1,1-Diphenyl-2-picrylhydrazyl Radical

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概要

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• The scavenging effects of twenty-five tannins including low-molecular polyphenols on the superoxide anion radical (O_2^-) generated in the hypoxanthine-xanthine oxidase system were estimated by electron spin resonance (ESR) measurements of the adducts formed by 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and the radical. The scavenging effects of tannins and related polyphenols having ortho-trihydroxyl (pyrogallol) structure [galloyl, hexahydroxydiphenoyl (HHDP) groups in hydrolyzable tannins, galloyl group in acylated proanthocyanidins, and the B-ring of some flavan-3-ols] were stronger than the effects of unacylated proanthocyanidins. The effects of tannins and related polyphenols on the superoxide anion radical were also compared with those on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. Each tannin in an ethanol solution of DPPH radical reduced the intensity of the signal of the DPPH radical, and gave a weak signal assignable to a radical derived from that tannin, in a similar way to the appearance of the signal of dl-α-tocopherol radical, accompanied with reduction of the signal of DPPH radical, in a mixture of dl-α-tocopherol and the DPPH radical. In contrast to the case of the superoxide anion radical, the effects of unacylated proanthocyanidins on DPPH radical were comparable with those of the other types of tannins. The scavenging effects of all of the tannins and related polyphenols tested in the experiments on DPPH radical were stronger than that of dl-α-tocopherol.

• 公益社団法人日本薬学会の論文
• 1989-08-25

著者

• 吉田 隆志

  Faculty of Pharmaceutical Sciences, Okayama University

• 奥田 拓男

  Faculty of Pharmaceutical Sciences, Okayama University

• 吉田 隆志

  Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University

• 波多野 力

  Faculty of Pharmaceutical Sciences, Okayama University

• 平松 緑

  山形県テクノポリス財団生物ラジカル研究所医学薬学研究部

• 森 昭胤

  岡山大学医学部分子細胞医学研究施設神経情報学部門

• Hatano Tsutomu

  エジプト

• 奥村 智子

  Faculty Of Pharmaceutical Sciences Okayama University

• 藤田 勇三郎

  Faculty of Pharmaceutical Sciences, Okayama University

• 安原 多恵子

  Faculty of Pharmaceutical Sciences, Okayama University

• 奥田 拓男

  Faculty Of Parmaceutical Sciences University

• 森 昭胤

  Department of Neurochemistry, Institute of Neurobiology, Okayama University Medical School

• 森 昭胤

  Department Of Molecular And Cell Biology University Of California At Berkeley

• 吉田 隆志

  Faculty Of Pharmaceutical Sciences Kyoto University

• 枝松 礼

  岡山大学医学部分子細胞医学研究施設神経情報学部門

• 安原 多恵子

  Faculty Of Pharmaceutical Sciences Okayama University

• 藤田 勇三郎

  Faculty Of Pharmaceutical Sciences Okayama University

• 藤田 勇三郎

  岡山大学薬学部薬品物理化学教室

• 枝松 礼

  Department of Neurochemistry

• 平松 緑

  Department of Neurochemistry

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