Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VII. Effects of Extracts of Leaves of Artemisia Species, and Caffeic Acid and Chlorogenic Acid on Lipid Metabolic Injury in Rats Fed Peroxidized Oil

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概要

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• The effects of oral administration of the extracts from the leaves of several Artemisia species, and of chlorogenic acid, which is one of their components, and also of caffeic acid (which can be produced by partial hydrolysis of caffeoylquinic acids, which are the main polyphenolic components in these species) on lipid metabolic injury produced in rats by feeding peroxidized oil were investigated. The acetone-water extracts of the leaves of Artemisia princeps, A. montana and A. capillaris reduced the elevation of lipid peroxide concentration in the serum in peroxidized oil-fed rats, and the above extracts reduced the levels of liver triglyceride. The extracts of A. montana and A. capillaris inhibited the elevation of serum glutamic oxaloacetic transaminase and glutamic pyruvic transaminase. Caffeic acid and chlorogenic acid also inhibited the elevation of serum triglyceride, lipid peroxides, total cholesterol, glutamic oxaloacetic transaminase and glutamic pyruvic transaminase, as well as liver lipid peroxide.

• 公益社団法人日本薬学会の論文
• 1985-05-25

著者

• 奥田 拓男

  Faculty of Pharmaceutical Sciences, Okayama University

• 波多野 力

  Faculty of Pharmaceutical Sciences, Okayama University

• 木村 善行

  愛媛大学大学院医学系研究科統合医科学講座薬理生化学分野

• 縣 功

  Faculty of Pharmacy, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto.

• 奥村 智子

  Faculty Of Pharmaceutical Sciences Okayama University

• 有地 滋

  The Research Institute of Oriental Medicine, Kinki University

• 有地 滋

  The Research Institute Of Oriental Medicine Kinki University

• 有地 滋

  近畿大学東洋医学研究所

• 奥田 拓道

  愛媛大学

• 奥田 拓道

  熊本県立大学環境共生学部環境共生学科食健康環境学科

• 奥田 拓道

  2nd Department of Medical Biochemistry, School of Medicine, Ehime University

• Kiso Yoshinobu

  Institute For Biomedical Research Suntory Ltd.

• 奥田 拓男

  Faculty Of Parmaceutical Sciences University

• 木村 善行

  2nd Department of Medical Biochemistry, School of Medicine, Ehime University

• 有地 滋

  愛媛大学

• 縣 功

  Faculty Of Pharmaceutical Sciences Higashi Nippon Gakuen University

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