Identification of the Up- and Down-Regulated Genes in the Heart of Juvenile Visceral Steatosis Mice (Biochemistry/Molecular Biology)
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概要
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Juvenile visceral steatosis (JVS) mice, novel animal models of systemic carnitine deficiency, exhibit a remarkably increased number of mitochondria in their cardiac myocytes. To date, however, there has been no reported investigation of the molecular mechanism of this increased number of mitochondria. Here, we analyzed the gene expression profile from the hearts of JVS and control mice by Affymetrix GeneChip analysis representing 34323 genes. We found that 176 genes, containing 93 known genes and 83 novel genes, were up-regulated in JVS mice compared with control mice, and 167 genes, containing 67 known genes and 100 novel genes, were down-regulated in JVS mice compared with control mice. We found several interesting molecular aspects that have not yet been identified in the hearts of JVS mice, including down-regulation of a number of ion channels and up-regulation of regulators involved in cell cycle progression. This genome-wide analysis should contribute to a greater understanding of the molecular mechanism of mitochondrial biogenesis in the heart of JVS mouse and provide a strategy for identifying novel genes involved not only in mitochondrial biogenesis but also in cardiac hypertrophy.
- 公益社団法人日本薬学会の論文
- 2004-04-01
著者
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Shibata Hiroko
Laboratory Of Pharmaceutical Proteomics National Institute Of Biomedical Innovation (nibio)
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Shibata Hiroko
医薬基盤研究所 創薬プロテオミクスプロジェクト
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Ozaki Kiyokazu
Research Institute Of Drug Safety Setsunan University
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Matsuura T
Institute For Protein Research Osaka University
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SHIBATA Hirofumi
Faculty of Pharmaceutical Sciences, The University of Tokushima
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ARAKAKI Naokatu
Faculty of Pharmaceutical Sciences, The University of Tokushima
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HIGUTI Tomihiko
Faculty of Pharmaceutical Sciences, The University of Tokushima
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Kuwajima Masamichi
Present Address: Department Of Laboratory Medicine School Of Medicine Tokushima University
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Kuwajima Masamichi
School Of Medicine The University Of Tokushima
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Kuwajima M
徳島大学医学部
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SUENAGA Midori
Faculty of Pharmaceutical Science, The University of Tokushima
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HIMEDA Toshiki
Faculty of Pharmaceutical Science, The University of Tokushima
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MOROKAMI Kayoko
Faculty of Pharmaceutical Science, The University of Tokushima
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MATSUURA Teruro
Research Institute of Drug Safety, Setsunan University
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Shibata Hiroshi
Laboratory For Health Care Science Research Center Suntory Ltd.
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Shibata H
Laboratory For Health Care Science Research Center Suntory Ltd.
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Suenaga M
Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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Matsuura T
Research Institute Of Drug Safety Setsunan University
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Himeda Toshiki
Faculty Of Pharmaceutical Science The University Of Tokushima
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Suenaga Midori
Department Of Molecular Cell Biology And Medicine Institute Of Health Biosciences The University Of
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Ozaki K
Research Institute Of Drug Safety Setsunan University
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Higuti T
Department Of Molecular Cell Biology And Medicine Institute Of Health Bioscience The University Of T
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Shibata Hirofumi
Faculty Of Pharmaceutical Sciences Tokushima University
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Arakaki Naokatu
Department Of Molecular Cell Biology And Medicine Institute Of Health Bioscience The University Of T
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Morokami Kayoko
Faculty Of Pharmaceutical Science The University Of Tokushima
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Saito Hiroyuki
Third Department Of Internal Medicine Asahikawa Medical College
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Shibata Hiroshi
Institute Of Health Care Science Suntory Wellness Limited
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Higuti Tomihiko
Faculty Of Pharmaceutical Sciences University Of Tokushima
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Arakaki N
Faculty of Pharmaceutical Sciences, The University of Tokushima
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Higuti T
Faculty of Pharmaceutical Sciences, The University of Tokushima
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Morokami K
Faculty of Pharmaceutical Science, The University of Tokushima
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Shibata H
Faculty of Pharmaceutical Science, The University of Tokushima
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