Effect of Rat Fetuin on Stimulation of Bone Resorption in the Presence of Parathyroid Hormone
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概要
- 論文の詳細を見る
Rat fetuin, which is the rat counterpart of human α_2-HS glycoprotein and bovine fetuin, is only detectable in calcified tissues such as bone matrices and dentin, and bone cells such as osteoblasts and osteocytes immunohistochemically. The effect of this protein on bone resorption was examined to study its physiological role in bone metabolism. Rat fetuin increased bone resorption in the presence of low concentrations of parathyroid hormone (PTH), but it had no activity on bone resorption without PTH. The increase in bone resorption by PTH and PTH plus rat fetuin was inhibited by the addition of chymostatin, an inhibitor for cathepsin L.Moreover, found that when type I collagen from rat was preincubated with rat fetuin, the digestion of rat type I collagen by cathepsin L was increased. These findings suggest that rat fetuin present in bone matrix is important in bone resorption.
- 社団法人日本農芸化学会の論文
- 1999-08-23
著者
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NAKAMURA Osamu
Department of Radiological Technology, Faculty of Health Sciences, Nihon Institute of Medical Scienc
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Ohnishi Tomokazu
Department of Biochemistry, Kagoshima University Dental School
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Daikuhara Yasushi
Department of Biochemistry, Kagoshima University Dental School
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NAKAMURA Osamu
Faculty of Environmental Information, Keio University
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ARAKAKI Naokatu
Department of Molecular Cell Biology and Medicine, Institute of Health Bioscience, The University of
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Kazi Jamil
Department Of Biochemistry Kagoshima University Dental School(present Address): First Department Of
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Nakamura O
Faculty Of Environmental Information Keio University
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Ohnishi T
Department Of Biochemistry Kagoshima University Dental School
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Ohnishi Tomokazu
Department Of Biochemistry Kagoshima University Dental School
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SHAO Qing
Department of Biochemistry, Kagoshima University Dental School(Present address)
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KAJIHARA Takehiro
Department of Biochemistry, Kagoshima University Dental School
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Daikuhara Y
Tokai Univ. Kanagawa Jpn
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Kajihara Takehiro
Department Of Biochemistry Kagoshima University Dental School
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Daikuhara Yasushi
Department Of Applied Physics Tokai University
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Shao Qing
Department Of Biochemistry Kagoshima University Dental School(present Address): Department Of Anatom
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Arakaki Naokatu
Department Of Molecular Cell Biology And Medicine Institute Of Health Bioscience The University Of T
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Arakaki N
Department Of Biochemistry Kagoshima University Dental School(present Address): Department Of Pharma
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Nakamura Osamu
Applied Physics Department Faculty Of Engineering Osaka University
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Nakamura Osamu
Department Of Applied Physics Osaka University
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ARAKAKI Naokatu
Department of Biochemistry, Kagoshima University Dental School(Present address): Department of Pharmaceutical Life Science, Faculty of Pharmaceutical Sciences, The University of Tokushima
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Arakaki Naokatu
Department of Biochemistry, Kagoshima University Dental School
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