Preparation of 9-Hydroxy Grayanotoxin Derivatives and Their Acute Toxicity in Mice

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概要

• 論文の詳細を見る

• Novel 9α and 9β-hydroxy grayanotoxin II derivatives were prepared by photo-sensitized oxygcnation of isograyanotoxin II and oxidation of grayanotoxin II tetraacetate with selenium dioxide respectively. The lethal dosage of 9α and 9β-hydroxy grayanotoxin II were lower than that of grayanotoxin II. In addition, the lethal dosage of 9β-hydroxy-dihydro grayanotoxin II was higher than that of dihydro grayanotoxin II.

• 公益社団法人日本薬学会の論文
• 2003-03-01

著者

• Narama Isao

  Institute For Protein Research Osaka University

• Matsuura T

  Institute For Protein Research Osaka University

• TERAI Tadamasa

  Department of Applied Chemistry, Osaka Institute of Technology

• OSAKABE Kanehiro

  Department of Applied Chemistry, Osaka Institute of Technology

• KATAI Masaaki

  Department of Applied Chemistry, Osaka Institute of Technology

• SAKAGICHI Ken-ichi

  Institute for Protein Research, Osaka University

• MATSUURA tetsuro

  Institute for Protein Research, Osaka University

• TETSUMI Tadahiro

  Institute for Protein Research, Osaka University

• Terai Tadamasa

  Dep. Of Applied Chemistry Osaka Inst. Of Technol.

• MATSUURA Teruro

  Research Institute of Drug Safety, Setsunan University

• Matsuura Tetsuro

  Institute For Protein Research Osaka University

• Sakagichi Ken-ichi

  Institute For Protein Research Osaka University

• Katai M

  Department Of Applied Chemistry Osaka Institute Of Technology

• Terai Tadamasa

  Department Of Applied Chemistry Osaka Institute Of Technology

• Matsuura T

  Research Institute Of Drug Safety Setsunan University

• Narama I

  Setsunan Univ. Osaka Jpn

• Terai T

  Dep. Of Applied Chemistry Osaka Inst. Of Technol.

• Sakaguchi Kengo

  Department Of Applied Biological Science Tokyo University Of Science

• Sakaguchi Kengo

  Department Of Applied Biological Science Faculty Of Science And Technology Tokyo University Of Scien

• Osakabe Kanehiro

  Department Of Applied Chemistry Osaka Institute Of Technology

• Katai Masaaki

  Department Of Applied Chemistry Osaka Institute Of Technology

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