Synthesis and Antitumor Activity of 9-Acyloxyellipticines
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概要
- 論文の詳細を見る
Various kinds of water-soluble 9-acyloxyellipticine derivatives were synthesized in a search for compounds with potent antitumor activity. Antitumor activities against several tumors in mice (P388 leukemia, colon 26,Lewis lung carcinoma and B16 melanoma) were evaluated by using intravenous administration. Many compounds exhibited good antitumor activities; in particular, the glutarate derivative (5o) showed potent antitumor activity. This comopound (5o) may be converted to 9-hydroxyellipticine (2) by enzyme-catalyzed hydrolysis in the body.
- 公益社団法人日本薬学会の論文
- 1997-07-15
著者
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Harada N
Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.
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Harada Naoyuki
Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.
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Ozaki Kiyokazu
Research Institute Of Drug Safety Setsunan University
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Nakanishi Noriyuki
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
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Nakanishi Noriyuki
Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.
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Nakanishi Noriyuki
Lead Optimization Laboratoiy Tanabe Seiyaku Co. Ltd.
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Tsujihara K
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
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Oda Kouji
Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.
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TSUJIHARA Kenji
Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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OZAKI Kunihiko
Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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OHASHI Motoaki
Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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HASHIYAMA Tomiki
Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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Ohashi M
Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.
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Ohashi Motoaki
Lead Optimization Laboratoiy Tanabe Seiyaku Co. Ltd.
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Ozaki K
Research Institute Of Drug Safety Setsunan University
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Ozaki Kunihiko
Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.
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Hashiyama T
Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.
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Hashiyama Tomiki
Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.
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