Synthesis and Antitumor Activity of Quaternary Salts of 2-(2'-Oxoalkoxy)-9-hydroxyellipticines

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概要

• 論文の詳細を見る

• Various kinds of water-soluble quaternary salts of 2-(2'-oxoalkoxy)-9-hydroxyellipticines were synthesized in a search for compounds with potent antitumor activity and low toxicity. Some compounds exhibited more potent antitumor activities than elliptinium (1) and SUN 4599 (3). In particular, 2-(3'-methoxy-2'-oxopropanoxy)-9-hydroxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazolium bromide (4d) showed potent antitumor activities against P388 leukemia, colon 26,and Lewis lung carcinoma.

• 公益社団法人日本薬学会の論文
• 1997-01-15

著者

• Harada N

  Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.

• Harada Naoyuki

  Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.

• Ozaki Kiyokazu

  Research Institute Of Drug Safety Setsunan University

• Kawaguchi Takayuki

  Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.

• Inoue I

  Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.

• Tsujihara K

  Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.

• Oda Kouji

  Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.

• TSUJIHARA Kenji

  Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• OHASHI Motoaki

  Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• HASHIYAMA Tomiki

  Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• INOUE Isao

  Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• Ohashi M

  Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.

• Ohashi Motoaki

  Lead Optimization Laboratoiy Tanabe Seiyaku Co. Ltd.

• Ozaki K

  Research Institute Of Drug Safety Setsunan University

• Hashiyama T

  Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.

• Hashiyama Tomiki

  Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.

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