Cryoprotective Effects of Cycloinulohexaose on Freezing and Freeze-Drying of Liposomes
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概要
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Cycloinulohexaose (CF-6) maintained the membrane structure of the liposomes during freeze-thawing, and thus CF-6 was very effective in inhibiting both drug leakage from liposomes and the size change of liposomes during freezing and freeze-drying. As the ratio of CF-6 to lipid increased from 1 to 5,calcein retention in the liposomes increased from 70% up to 85% and a maximum retention was obtained at a ratio of more than 2. The addition of glycerol enhanced the above cryoprotective effect of CF-6 and improved calcein retention up to 90%. Neither detectable leakage of calcein nor particle size change was observed after the storage of liposomes freeze-dried with CF-6 for 6 months at 4 and 25℃.
- 公益社団法人日本薬学会の論文
- 1996-11-15
著者
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Ozaki Kazuhiko
Pharmaceutical R&d Group Mitsubishi Pharma Corporation
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Ozaki K
Research Institute Of Drug Safety Setsunan University
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Hayashi Masahiro
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Hayashi Masahiro
Faculty Of Agriculture Miyazaki University
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Hayashi Masahiko
Faculty of Education and Human Studies, Akita University, Akita 010-8502, Japan
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