Structures of New Erythrinan Alkaloids and Nitric Oxide Production Inhibitors from Erythrina crista-galli

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概要

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• Two new Erythrinan alkaloids, cristanines A and B (1, 2), were isolated from the bark of Erythrina crista-galli L. together with nine known Erythrinan alkaloids (3—5, 7—12) and an indole alkaloid (13). The structures of the compounds, cristanines A (1) and B (2), were elucidated by spectroscopic methods. Three of the twelve compounds isolated showed significant inhibitory activity on lipopolysaccharide induced nitric oxide (NO) production.

• 公益社団法人　日本薬学会の論文

著者

• HAYASHI Masahiko

  Faculty of Science, Fukuoka University

• KURODA Chiaki

  Department of Chemistry, Rikkyo University

• Ohsaki Ayumi

  Institute Of Biomaterials & Bioengineering Tokyo Medical & Dental University

• KISHIDA Akio

  Institute of Biomaterials & Bioengineering, Tokyo Medical & Dental University

• Kuroda Chiaki

  Department Of Chemical Engineering Graduate School Of Science And Engineering Tokyo Institute Of Tec

• Ozawa Masaaki

  Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

• Kawamata Shunsuke

  Deparment of Chemistry, Rikkyo University

• Etoh Tadahiro

  Faculty of Pharmacy, Iwaki Meisei University

• Komiyama Kanki

  Kitasato Research Center of Environmental Science, Kitasato University

• Hayashi Masahiko

  Faculty Of Science Fukuoka University

• Kishida Akio

  Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

• Ozawa Masaaki

  Institute of Biomaterials & Bioengineering, Tokyo Medical & Dental University

• Kuroda Chiaki

  Deparment of Chemistry, Rikkyo University

• Hayashi Masahiko

  Faculty of Education and Human Studies, Akita University, Akita 010-8502, Japan

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