Analysis of Major Components and Bisphenol A in Commercial Bis-GMA and Bis-GMA-based Resins Using High Performance Liquid Chromatography

概要

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The purpose of this study was to examine the quality of commercially available Bis-GMA because concerns about Bis-GMA and Bis-GMA-based resins have been recently expressed in dentistry. Four major components and bisphenol A, which is a compound of recent controversy, were quantitatively analyzed using high performance liquid chromatography(HPLC) in three commercial Bis-GMA and six Bis-GMA-based composite resins. The contents of genuine Bis-GMA, Iso-bis-GMA, Bis-GMA-H, and Bis-GMA-M as well as the total content of the four monomers were 45.7-57.5%, 19.9-26.2%, 1.8-5.0%, 0.6-15.0% and 83.7-85.6% in the commercial Bis-GMAs, or 3.8-9.1%, 1.7-4.3%, 0.1-0.5%, 0.1-2.0% and 5.8-14.0% in composite resins, respectively. There were some differences in the composition of the major components between domestic and foreign materials. Bisphenol A contents in the unpolymerized composite resins were 1.5-10.2μg/g resin.