Effects of the Antlered Form of Ganoderma lucidum on Tumor Growth and Metastasis in Cyclophosphamide-Treated Mice
スポンサーリンク
概要
- 論文の詳細を見る
We examined the alleviation of cyclophosphamide-induced immunodepression by the antlered form of Ganoderma lucidum (G. lucidum AF) and also evaluated the anti-tumor and anti-metastatic effects of G. lucidum AF in cyclophosphamide-treated mice. G. lucidum AF alleviated cyclophosphamide-induced decrease in body weight, natural killer (NK) activity, interferon (IFN)-γ production, and cytotoxic T lymphocyte (CTL) activity, and inhibited the abnormal increase and decrease in interleukine (IL)-4 level due to cyclophosphamide administration. Post-treatment with cyclophosphamide and G. lucidum AF significantly inhibited tumor growth in MM 46-bearing mice. When Lewis lung carcinoma cells were injected into mice after a cyclophosphamide administration, metastasis of these cells to the lung was increased, but G. lucidum AF suppressed it. The anti-tumor and anti-metastatic effects of the combination of G. lucidum AF and cyclophosphamide might influence the modulatory effects of G. lucidum AF on both cellular and humoral immunity. These findings suggest that G. lucidum AF would be beneficial in alleviating the reduction of immune response by chemotherapeutic anti-cancer drugs.
- 社団法人 日本農芸化学会の論文
- 2008-06-23
著者
-
KISO Yoshinobu
Institute for Health Care Science, Suntory Ltd.
-
Shibata Hiroko
Laboratory Of Pharmaceutical Proteomics National Institute Of Biomedical Innovation (nibio)
-
Shibata Hiroko
医薬基盤研究所 創薬プロテオミクスプロジェクト
-
SHIBATA Hiroshi
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
-
Kiso Yoshinobu
Laboratory For Health Care Science Research Center Suntory Ltd.
-
Kiso Yoshinobu
Institute For Biomedical Research Suntory Ltd.
-
NAKAI Masaaki
Institute for Materials Research, Tohoku University
-
ABE SHIGERU
Institute of Medical Mycology, Teikyo University
-
Kiso Yoshinobu
Suntory Ltd. Osaka Jpn
-
Shibata Hiroshi
Laboratory For Health Care Science Research Center Suntory Ltd.
-
Shibata H
Laboratory For Health Care Science Research Center Suntory Ltd.
-
NONAKA Yuji
Institute for Health Care Science, Suntory Ltd.
-
ISHIBASHI Hiroko
Institute of Medical Mycology, Teikyo University
-
Abe Shigeru
Institute Of Medical Mycology Graduate School Of Medical Science Teikyo University
-
Nonaka Yuji
Division Of Life Science Graduate School Of Science And Technology Kobe University
-
Abe Shigeru
Institute Of Medical Mycology Teikyo University
-
Ishibashi Hiroko
Institute Of Medical Mycology Teikyo University
-
Nakai Masaaki
Institute For Health Care Science Suntory Ltd.
-
Kajimoto Yoshinaga
Institute For Health Care Science Suntory Ltd.
-
Kitagawa Yoshinori
Institute For Health Care Science Suntory Wellness Limited
-
Saito Hiroyuki
Third Department Of Internal Medicine Asahikawa Medical College
-
Shibata Hiroshi
Institute Of Health Care Science Suntory Wellness Limited
-
Shibata Hiroshi
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.:department Of Animal Scienc
-
SHIBATA Hiroshi
Institute for Biomedical Research, Suntory Limited
関連論文
- Antitumor and antimetastatic actions by royal jelly in Lewis lung carcinoma-bearing mice
- Antihypertensive Effects of Sesamin in Humans
- Creation of Novel Cell-Penetrating Peptides for Intracellular Drug Delivery Using Systematic Phage Display Technology Originated from Tat Transduction Domain(Biochemistry)
- ショウガの抗肥満作用について
- デンプンおよびショ糖負荷マウスにおけるオリーブ葉エキスの血糖値に及ぼす影響
- Fast Binding Kinetics and Conserved 3D Structure Underlie the Antagonistic Activity of Mutant TNF : Useful Information for Designing Artificial Proteo-Antagonists
- Creation of Novel Protein Transduction Domain (PTD) Mutants by a Phage Display-Based High-Throughput Screening System(Biochemistry)
- Quality Enhancement of the Non-immune Phage scFv Library to Isolate Effective Antibodies(Highlighted paper selected by Editor-in-chief,Biochemistry)
- Characterization of the Pharmacology of YM-198313 on Volume-Regulated Anion Channels(Pharmacology)
- J-1 天然にがりの抗腫瘍効果
- 昆布由来フコイダン含有食品の抗腫瘍効果とその作用機構
- P-86 高脂肪食誘発肥満に及ぼす竹節人参サポニンの作用
- P-16 ローヤルゼリーの抗腫瘍および抗転移効果とその作用機構
- Agaricus blazei Murill の抗腫瘍作用とその副作用 : 第2報 : 癌
- Agaricus blazei Murill の抗腫瘍作用とその副作用 : 第1報 : 癌
- 28D-05 柳の葉 (Salix matsudana (Salicaceae)) の高脂肪食投与マウスに及ぼす影響
- Development of new anti-TNF therapy
- Development of Novel Drug Delivery System (DDS) Technologies for Proteomic-Based Drug Development
- Selective Enhancer of Tumor Vascular Permeability for Optimization of Cancer Chemotherapy (Pharmacognosy)
- Effective Cancer Targeting Using an Anti-tumor Tissue Vascular Endotheliumm specific Monoclonal Antibody (TES-23)
- Prolongation of the Effective Duration of Cytomedical Therapy by Re-injecting SK2 Hybridoma Cells Microencapsulated within Alginate-Poly(L)lysine-Alginate Membranes into Human Interleukin-6 Transgenic Mice
- Therapeutic Effect of Cytomedicine on Mesangio-Proliferative Glomerulonephritis in Human Interleukin-6 Transgenic Mice
- 食後の血中トリアシルグリセロールの上昇に及ぼすアカショウマエキスの影響
- B-013(30) 生姜の膵リパーゼ阻害作用およびその抗肥満作用
- S-3 膵リパーゼ阻害作用のある機能性物質について
- A-1 お茶由来のサポニンの抗肥満作用
- Studies on Scutellariae Radix. XII. Anti-thrombic Actions of Various Flavonoids from Scutellariae Radix
- Effect of Lactobacillus pentosus S-PT84 Ingestion on IFN-α Production from Plasmacytoid Dendritic Cells by Virus Stimulation
- Anti-Atherosclerotic Effects of Dihomo-γ-Linolenic Acid in ApoE-Deficient Mice
- Cardiac Cysteinyl Leukotriene Receptors and Their Contribution to Coronary Vasoconstriction in Intact Pig Heart(Coronary Circulation, Basic/Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Increased Expression of Cysteinyl Leukotriene Receptor, CysLT-R2 in Injured Coronary Artery of Pigs(Restenosis after Angioplasty, Basic/Clinical 4 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Effects of tuna oil on tumor growth and metastasis to liver in intrasplenic Lewis lung carcinoma (LLC)-implanted mice
- Effects of the nonsugar fraction of brown sugar on chronic ultraviolet B irradiation-induced photoaging in melanin-possessing hairless mice
- D-037(31) EPA および共役 EPA の抗腫瘍および抗転移効果
- Arsenic Trioxide Inhibits Human T Cell-Lymphotropic Virus-1-Induced Syncytiums by Down-Regulating gp46
- 31C-08 血管内皮細胞における t-PA, PAI-1 産生および接着分子発現に及ぼすバイカレインの影響
- Carnosine Modulates Stress-Attenuated Plasma Antioxidative Capacity
- Effects of Oolong Tea on Plasma Antioxidative Capacity in Mice Loaded with Restraint Stress Assessed Using the Oxygen Radical Absorbance Capacity (ORAC) Assay(Pharmacognosy)
- Studies on Scutellariae Radix. VII. Anti-arthritic and Anti-inflammatory Actions of Methanolic Extract and Flavonoid Components from Scutellariae Radix
- Flavone Markedly Affects Phenotypic Expression of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus Strains Isolated Clinically(Miscellaneous)
- Identification of the Up- and Down-Regulated Genes in the Heart of Juvenile Visceral Steatosis Mice (Biochemistry/Molecular Biology)
- Functional Disorders of the Oxidative Phosphorylation System in the Heart Mitochondria of Mice with Juvenile Visceral Steatosis
- Effects of Dietary Arachidonic Acid Supplementation on Age-Related Changes in Endothelium-Dependent Vascular Responses
- Synaptic plasticity preserved with arachidonic acid diet in aged rats
- Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction
- EFFECTS OF BAICALEIN ON LEUKOTRIENE C_4 BIOSYNTHESIS IN HUMAN LEUKOCYTE
- Effects of Flavonoids and Related Compounds from Mulberry Tree on Arachidonate Metabolism in Rat Platelet Homogenates
- A 1.5-V 250-MHz to 3.0-V 622-MHz Operation CMOS Phase-Locked Loop with Precharge Type Phase-Frequency Detector
- Oral Supplementation with Dihomo-γ-linolenic Acid-Enriched Oil Altered Serum Fatty Acids in Healthy Men
- Possible Role of Mitochondrial Remodelling on Cellular Triacylglycerol Accumulation
- Comparison of Antibacterial Activity of Fluoroquinolones with Their Sucralfate-complexes against Clinically-isolated Bacteria
- Anti-Tumor Activities of the Antlered Form of Ganoderma lucidum in Allogeneic and Syngeneic Tumor-Bearing Mice
- Dynamics of Mitochondria during the Cell Cycle(Molecular and Cell Biology)
- Anti-Stress Effect of BRAND'S Essence of Chicken (BEC) on Plasma Glucose Levels in Mice Loaded with Restraint Stress
- Antihypertensive Effect of Angiotensin I-Converting Enzyme Inhibitory Peptides from a Sesame Protein Hydrolysate in Spontaneously Hypertensive Rats
- The Protective Effect of BRAND'S Essence of Chicken (BEC) on Energy Metabolic Disorder in Mice Loaded with Restraint Stress
- Anti-Stress Effect of Oolong Tea in Women Loaded with Vigil
- Influence of Histamine in a Liver Injury Model Induced by Propionibacterium acnes and Lipopolysaccharide(Pharmacology)
- Pharmacology in Health Foods:Effects of Arachidonic Acid and Docosahexaenoic Acid on the Age-Related Decline in Brain and Cardiovascular System Function
- The Relationships of Cardiovascular Disease Risk Factors to Flow-Mediated Dilatation in Japanese Subjects Free of Cardiovascular Disease
- A New Emitter-Follower Circuit for High-Speed and Low-Power ECL
- Dietary Supplementation of L-Carnosine Prevents Ischemia/Reperfusion-Induced Renal Injury in Rats(Pharmacology)
- Effects of Sesamin on Aortic Oxidative Stress and Endothelial Dysfunction in Deoxycorticosterone Acetate-Salt Hypertensive Rats (Pharmacology)
- Inhibitory Effect of Oolong Tea on the Oxidative State of Low Density Lipoprotein (LDL)
- Antihypertensive Effect of Sesamin. IV. Inhibition of Vascular Superoxide Production by Sesamin
- Preventive Effect of a Chicken Extract on the Development of Hypertension in Stroke-prone Spontaneously Hypertensive Rats(Food & Nutrition Science)
- Antihypertensive Effects of Chicken Extract against Deoxycorticosterone Acetate-Salt-Induced Hypertension in Rats
- A New Family of Serine Protease Inhibitors (Bombyx Family) as Established from the Unique Topological Relation between the Positions of Disulfide Bridges and Reactive Site
- Low-Calorie Diet-Induced Reduction in Serum HDL Cholesterol Is Ameliorated in Obese Women with the -3826 G Allele in the Uncoupling Protein-1 Gene
- Preventive Effect of Flavangenol on Ischemia/Reperfusion-Induced Acute Renal Failure in Rats(Pharmacology)
- Synthesis of Novel Succinamide Derivatives Having the 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one Skeleton as Potent and Selective M_2 Muscarinic Receptor Antagonists. I
- Effects of an Oral Administration of Glucosamine-Chondroitin-Quercetin Glucoside on the Synovial Fluid Properties in Patients with Osteoarthritis and Rheumatoid Arthritis
- Effects of Oolong Tea on Metabolism of Plasma Fat in Mice under Restraint Stress(Food & Nutrition Science)
- First Chemical Synthesis of Antioxidative Metabolites of Sesamin
- Comparison of the Immunomodulatory Effects of Live and Heat-killed Lactobacillus pentosus S-PT84
- Fragrances in Oolong Tea That Enhance the Response of GABA_A Receptors
- Effect of Xylooligosaccharide Intake on Severe Constipation in Pregnant Women
- Pharmacology in Health Foods:Improvement of Vascular Endothelial Function by French Maritime Pine Bark Extract (Flavangenol)
- Effect of Dietary Enrichment with n-3 Polyunsaturated Fatty Acids (PUFA) or n-9 PUFA on Arachidonate Metabolism in Vivo and Experimentally Induced Inflammation in Mice (Biochemistry/Molecular Biology)
- Clinical Study on the Combined Effect of Capsaicin, Green Tea Extract and Essence of Chicken on Body Fat Content in Human Subjects
- Effects of Chicken Essence Tablets on Resting Metabolic Rate(Food & Nutrition Science)
- Identification of the Major Antioxidative Metabolites in Biological Fluids of the Rat with Ingested (+)-Catechin and (-)-Epicatechin
- Recent Trends in Functional Food Science and the Industry in Japan
- Effects of Flavangenol on Autonomic Nerve Activities and Dietary Body Weight Gain in Rats
- Effects of Flavangenol on Autonomic Nerve Activities and Dietary Body Weight Gain in Rats
- Effects of an Oral Administration of Glucosamine-Chondroitin-Quercetin Glucoside on the Synovial Fluid Properties in Patients with Osteoarthritis and Rheumatoid Arthritis
- Effects of the Antlered Form of Ganoderma lucidum on Tumor Growth and Metastasis in Cyclophosphamide-Treated Mice
- Hypoglycemic Action of Cyclocarya paliurus (Batal.) Iljinskaja in Normal and Diabetic Mice(Food & Nutrition Science)
- Hypolipcmic Effect of Cyclocarya paliurus (Batal) Iljinskaja in Lipid-Loaded Mice
- Suppression of Postprandial Hypertriglyceridemia in Rats and Mice by Oolong Tea Polymerized Polyphenols
- Dietary Sesame Lignans Decrease Lipid Peroxidation in Rats Fed Docosahexaenoic Acid
- Synthesis and Biological Evaluation of Phenylacetyl Derivatives Having Low Central Nervous System Permeability as Potent and Selective M_2 Muscarinic Receptor Antagonists
- Synthesis of Novel Succinamide Derivatives Having a 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one Skeleton as Potent and Selective M_2 Muscarinic Receptor Antagonists. II
- Oral Supplementation with Dihomo-γ-linolenic Acid-Enriched Oil Altered Serum Fatty Acids in Healthy Men
- P2-40 Effect of Flavangenol of movement tiredness recovery in long distance runner(The Proceedings of the 12th Annual Meetings of Japan Society of Exercise and Sports Physiology)
- Role of cell surface H^+-ATP synthase on adipocyte differentiation
- Effect of Lactobacillus pentosus S-PT84 Ingestion on IFN-α Production from Plasmacytoid Dendritic Cells by Virus Stimulation
- Influence of Lactobacillus pentosus S-PT84 Ingestion on the Mucosal Immunity of Healthy and Salmonella Typhimurium-Infected Mice
- Pharmacology in Health Foods : Improvement of Vascular Endothelial Function by French Maritime Pine Bark Extract (Flavangenol)
- The Mechanism Underlying the Synergetic Hypocholesterolemic Effect of Sesamin and α-Tocopherol in Rats Fed a High-Cholesterol Diet