Effects of an Oral Administration of Glucosamine-Chondroitin-Quercetin Glucoside on the Synovial Fluid Properties in Patients with Osteoarthritis and Rheumatoid Arthritis
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概要
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The effects of an orally administered combination of a glucosamine-chondroitin-quercetin glucoside (GCQG) supplement on the synovial fluid properties of patients with osteoarthritis (OA) and rheumatoid arthritis (RA) were investigated from the clinical nutrition view point. In this study, forty-six OA and twenty-two RA patients were administered with the GCQG supplement orally for 3 months. Several parameters of the knee joints were monitored before and after supplementation. The OA patients showed a significant improvement in pain symptoms, daily activities (walking and climbing up and down stairs), and visual analogue scale, and changes in the synovial fluid properties with respect to the protein concentration, molecular size of hyaluronic acid, and chondroitin 6-sulphate concentration were also observed. However, no such effects were observed in the RA patients. These results suggest that the GCQG supplement exerted a special effect on improving the synovial fluid properties in OA patients.
- 社団法人 日本農芸化学会の論文
著者
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KISO Yoshinobu
Institute for Health Care Science, Suntory Ltd.
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NAKAMURA Hiroshi
Research Center for Advanced Science and Technology, the University of Tokyo
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Matsuno Hiroaki
Matsuno Clinic For Rheumatic Diseases
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KATAYAMA Kou
Research Group of Arthritis Pathology, Matsuno Clinic for Rheumatic Diseases
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HAYASHI Seigaku
Research Group of Arthritis Pathology, Matsuno Clinic for Rheumatic Diseases
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KANO Syogo
Research Group of Arthritis Pathology, Matsuno Clinic for Rheumatic Diseases
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YUDOH Kazuo
Research Group of Arthritis Pathology, Matsuno Clinic for Rheumatic Diseases
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