L-Tryptophan Suppresses Rise in Blood Glucose and Preserves Insulin Secretion in Type-2 Diabetes Mellitus Rats

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概要

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• Ample evidence indicates that a high-protein/low-carbohydrate diet increases glucose energy expenditure and is beneficial in patients with type-2 diabetes mellitus (T2DM). The present study was designed to investigate the effects of L-tryptophan in T2DM. Blood glucose was measured by the glucose dehydrogenase assay and serum insulin was measured with ELISA in both normal and hereditary T2DM rats after oral glucose administration with or without L-D-tryptophan and tryptamine. The effect of tryptophan on glucose absorption was examined in the small intestine of rats using the everted-sac method. Glucose incorporation in adipocytes was assayed with [3H]-2-deoxy-D-glucose using a liquid scintillation counter. Indirect computer-regulated respiratory gas-assay calorimetry was applied to assay energy expenditure in rats. L-Tryptophan suppressed both serum glucose and insulin levels after oral glucose administration and inhibited glucose absorption from the intestine. Tryptamine, but not L-tryptophan, enhanced insulin-stimulated [3H]-glucose incorporation into differentiated adipocytes. L-Tryptophan increased glucose-associated energy expenditure in rats in vivo. L-Tryptophan-rich chow consumed from a young age preserved the secretion of insulin and delayed the progression of T2DM in hereditary diabetic rats. The results suggested that L-tryptophan suppresses the elevation of blood glucose and lessens the burden associated with insulin secretion from β-cells.

著者

• SUENAGA Midori

  Faculty of Pharmaceutical Science, The University of Tokushima

• Harada Nagakatsu

  Department Of Nutrition And Metabolism Institute Of Health Biosciences University Of Tokushima Gradu

• Katunuma Nobuhiko

  Institute For Enzyme Research Dept. Of Enzyme Chemistry Tokushima Univ.

• Nakaya Yutaka

  Department of Cardiology, Tokushima University

• ISHIDOH KAZUMI

  Institute for Health Sciences, Tokushima-Bunri University

• Oda Masataka

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Matsunaga Yoichi

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Sakurai Jun

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• INUBUSHI Tomoko

  Faculty of Life Science, Tokushima Bunri University

• KAMEMURA Noriko

  Institute for Health Sciences, Tokushima Bunri University

• ISHIDOH Kazumi

  Institute for Health Sciences, Tokushima Bunri University

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