Establishment of a Model of Spontaneously-Running-Tokushima-Shikoku Rats with Left Atrial Thrombosis
スポンサーリンク
概要
- 論文の詳細を見る
Studies that investigate the underlying mechanisms of disease and treatment options typically require the use of a suitable animal model. Few suitable animal models exist for left atrial thrombosis. Here, we demonstrated that the Spontaneously-Running-Tokushima-Shikoku (SPORTS) rat —a Wistar strain known for its running ability—is predisposed to the development of thrombi in the left atrium. We investigated the incidence of left atrial thrombosis in male (n=16) and female (n=17) SPORTS rats and observed organized atrial thrombosis in 57% and 38% of males and female rats, respectively. In the male rats, systolic blood pressures and heart rates were significantly higher in SPORTS rats than in control Wistar rats. We could not find any evidence of arrhythmias, such as atrial fibrillation, during electrocardiographic examination of SPORTS rats. We believe that the SPORTS rat could serve as a new research model for left atrial thrombosis; further, it may be suitable for research investigating the development of new antithrombotic approaches for the control of atrial thrombosis or familial thrombophilia in humans.
- 日本毒性病理学会の論文
著者
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Izumi Keisuke
Department Of Molecular And Environmental Pathology School Of Medicine The University Of Tokushima
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Arai Hidekazu
Department Of Applied Chemistry Faculty Of Engineering Toyama University
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Ohnishi Takamasa
Department of Anatomy, University of Tokushima School of Medicine
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Mawatari Kazuaki
Department Of Preventive Environment And Nutrition Institute Of Health Biosciences The University Of
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Morishima Masaki
Department Of Cardiovascular Sciences Oita University School Of Medicine
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Harada Nagakatsu
Department Of Nutrition And Metabolism Institute Of Health Biosciences University Of Tokushima Gradu
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Takahashi Akira
Department Of Advanced Materials Science And Engineering Faculty Of Engineering Yamaguchi University
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Nakaya Yutaka
Department of Cardiology, Tokushima University
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OHNISHI Takamasa
Department of Nutrition Management, Faculty of Health Science, Hyogo University, 2301 Shinzaike, Hiraoka-cho, Kakogawa, Hyogo 675-0195, Japan
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HISAOKA Fumiko
Faculty of Human Life Science, Shikoku University, 23-1 Ebisuno Furukawa, Oujinn-cho, Tokushima, Tokushima 771-1192, Japan
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YOSHIOKA Emiko
Department of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan
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TODA Satomi
Department of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan
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IZUMI Keisuke
Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan
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NAKAYA Yutaka
Department of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan
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ARAI Hidekazu
Department of Laboratory of Clinical Nutrition Management, School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan
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TAKAHASHI Akira
Department of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan
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MAWATARI Kazuaki
Department of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan
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HARADA Nagakatsu
Department of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan
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