Extracts of Momordica charantia Suppress Postprandial Hyperglycemia in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Momordica charantia (bitter melon) is commonly known as vegetable insulin, but the mechanisms underlying its hypoglycemic effect remain unclear. To address this issue, the effects of bitter melon extracts on postprandial glycemic responses have been investigated in rats. An aqueous extract (AE), methanol fraction (MF) and methanol insoluble fraction (MIF) were prepared from bitter melon. An oral sucrose tolerance test revealed that administration of AE, MF or MIF each significantly suppressed plasma glucose levels at 30 min as compared with the control. In addition, the plasma insulin level at 30 min was also significantly lower after MF administration than in the control in the oral sucrose tolerance test. By contrast, these effects of bitter melon extracts were not observed in the oral glucose tolerance test. In terms of mechanism, bitter melon extracts dose-dependently inhibited the sucrase activity of intestinal mucosa with IC_<50> values of 8.3, 3.7 and 12.0mg/mL for AE, MF and MIF, respectively. The fraction with a molecular weight of less than 1,300 (LT 1,300) obtained from MF inhibited the sucrase activity most strongly in an uncompetitive manner with an IC_<50> value of 2.6mg/mL. Taken together, these results demonstrated that bitter melon suppressed postprandial hyperglycemia by inhibition of α-glucosidase activity and that the most beneficial component is present in the LT 1,300 fraction obtained from MF.
- 日本ビタミン学会の論文
著者
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TAKEDA Eiji
Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate
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Arai Hidekazu
Department Of Cardiology Hanwa Memorial Hospital
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Arai Hidekazu
Department Of Clinical Nutrition University Of Tokushima Graduate School
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Takeda E
Department Of Clinical Nutrition University Of Tokushima Graduate School
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Takeda E
Hitachi Ltd. Tokyo Jpn
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Takeda E
Univ. Of Tokushima Graduate School Tokushima Jpn
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Takeda Eiji
Central Research Laboratory Hitachi Lid.
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TAKETANI Yutaka
Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Gradu
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YAMAMOTO HIRONORI
Department of Medicine, Division of Gastroenterology, Jichi Medical University
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Arai Hidekazu
Department Of Applied Chemistry Faculty Of Engineering Toyama University
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Tani Yoshiko
Department Of Clinical Nutrition School Of Medicine Tokushima University
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Yasuda Toshiyuki
Department Of Pediatrics School Of Medicine Chiba University
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UEBANSO Takashi
Department of Clinical Nutrition, University of Tokushima Graduate School
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FUKAYA Makiko
Department of Clinical Nutrition, University of Tokushima Graduate School
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MIZUNO Akira
Clinical Biology and Medicine, Institute of Health Biosciences, University of Tokushima Graduate Sch
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URYU Keisuke
Bizen Chemical Co., Ltd.
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HADA Takahiko
Bizen Chemical Co., Ltd.
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Uryu Keisuke
Bizen Chemical Co. Ltd.
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Fukaya Makiko
Department Of Clinical Nutrition University Of Tokushima Graduate School
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Hada Takahiko
Bizen Chemical Co. Ltd.
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Uebanso Takashi
Department Of Clinical Nutrition University Of Tokushima Graduate School
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Arai Hidekazu
徳島大学 大学院ヘルスバイオサイエンス研究部臨床栄養学
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Taketani Yutaka
Department Of Clinical Nutrition Institute Of Health Biosciences The University Of Tokushima
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Takeda Eiji
Department Of Clinical Nutrition Institute Of Health Biosciences The University Of Tokushima
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Yamamoto Hironori
Department Of Clinical Nutrition Institute Of Health Biosciences The University Of Tokushima
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Yamamoto Hironori
Department Of Advanced Materials Science Graduate School Of Frontier Sciences The University Of Toky
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Mizuno Akira
Clinical Biology And Medicine Institute Of Health Biosciences University Of Tokushima Graduate Schoo
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Takeda Eiji
Department Of Applied Physics Faculty Of Engineering Osaka University
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Takeda Eiji
徳島大学 病態栄養
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Hadai Takahiko
Bizen Chemical Co., Ltd.
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