High Susceptibility to Zymbal Gland and Intestinal Carcinogenesis in Diabetic Otsuka Long-Evans Tokushima Fatty Rats
スポンサーリンク
概要
- 論文の詳細を見る
Diabetes mellitus (DM) and obesity are believed to be risk factors for colorectal cancer in humans. In experiment 1, male nondiabetic Long-Evans Tokushima Otsuka (LETO) rats and Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model animal of type 2 DM, were whole-body X-irradiated (4 Gy) at 6 and 8 weeks of age and euthanized at 78 weeks of age (n=15, respectively). The incidences of small intestine adenocarcinoma in LETO and OLETF rats were 0% and 30%, respectively. In experiment 2, male LETO and OLETF rats (n=24, respectively) were given s.c. injections of 15 mg/kg azoxymethane (AOM) once weekly for 3 weeks and euthanized at 36 weeks of age. The incidences of Zymbal gland tumors in LETO and OLETF rats were 0% and 67%, respectively (P<0.001), whereas those of small intestine adenocarcinoma were 0% and 43% (P<0.001) and those of cecum/colon adenocarcinoma were 46% and 79% (P<0.05), respectively. Fatty change of hepatocytes was common in OLETF rats (63%) but not in LETO rats. Serum triglyceride and free fatty acid levels in OLETF rats were significantly higher than in LETO rats at sacrifice, whereas serum insulin levels in OLETF rats were very diverse. These data suggest that hyperlipidemia plays a significant role in high susceptibility to lower intestinal tract carcinogenesis in OLETF rats; this strain is susceptible to AOM-induced Zymbal gland carcinogenesis.
著者
-
Izumi Keisuke
Department Of Molecular And Environmental Pathology School Of Medicine The University Of Tokushima
-
Uehara Hisanori
Department Of Molecular And Environmental Pathology Institute Of Health Biosciences University Of To
-
Ogawa Hirohisa
Department Of Internal Medicine And Molecular Therapeutics Course Of Medical Oncology University Of Tokushima School Of Medicine
-
Sato Makoto
Department Of Applid Chemistry Graduate School Of Engineering Tohoku University
-
Takasu Chie
Department Of Molecular And Environmental Pathology Institute Of Health Biosciences The University Of Tokushima Graduate School
-
Hafez Ezar
Department Of Molecular And Environmental Pathology Institute Of Health Biosciences The University Of Tokushima Graduate School
-
Nakai Tokiko
Department Of Molecular And Environmental Pathology Institute Of Health Biosciences The University Of Tokushima Graduate School
-
Takahashi Tetsuyuki
Department Of Molecular And Environmental Pathology Institute Of Health Biosciences University Of Tokushima Graduate School
-
Takahashi Tetsuyuki
Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan
-
Ogawa Hirohisa
Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan
-
Ogawa Hirohisa
Department of Chemical Engineering, Tokyo Institute of Technology
-
Nakai Tokiko
Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan
-
Hafez Ezar
Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan
-
Takasu Chie
Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan
関連論文
- Differential Detection of Hemotropic Mycoplasma Species in Cattle by Melting Curve Analysis of the PCR Products
- Phylogenetic Analysis of the 16S rRNA Gene of Anaplasma Species Detected from Japanese Serows (Capricornis crispus)
- Determination of Aluminium in Human Serum by Kinetic Differention Mode Reversed Phase Micellar HPLC with Fluorometric Detection
- EFFECTS OF INTRACORONARY THROMBOLYSIS THERAPY IN ACUTE MYOCARDIAL INFARCTION : Ichemic Heart Disease (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
- Significance of simultaneous determination of serum human chorionic gonadotropin (hCG) and hCG-βin testicular tumor patients
- The significance of resections for residual masses after chemotherapy in metastatic testicular tumors
- Collaborative work on evaluation of ovarian toxicity : 7) Effects of 2- or 4-week repeated dose studies and fertility study of cyclophosphamide in female rats
- Lack of Role of Platelet Aggregation on 2-Bromoethylamine Hydrobromide-induced Renal Papillary Necrosis in Rats
- Low Susceptibility of Long-Evans Cinnamon Rats to N-Butyl-N-(4-hydroxybutyl)-nitrosamine-induced Urinary Bladder Carcinogenesis and Inhibitory Effect of Urinary Copper
- Effects of D-Galactosamine Hydrochloride and Partial Hepatectomy on Spontaneous Hepatic Injury and Hepatocarcinogenesis in Long-Evans Cinnamon Rats
- Role of Copper Accumulation in Spontaneous Renal Carcinogenesis in Long-Evans Cinnamon Rats
- Effects of tacrolimus (FK506) on induction of glutathione S-transferase P-positive foci and liver cell regeneration after partial hepatectomy in F344 rats
- Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E_2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development
- Multfunctional interleukin-1β promotes metastasis of human lung cancer cells in SCID mice via enhanced expression of adhesion-, invasion- and angiogenesis-related molecules
- Role of tumor angiogenesis in gallbladder carcinoma : with special reference to thymidine phosphorylase
- Novel orthotopic implantation model of human malignant pleural mesothelioma (EHMES-10 cells) highly expressing vascular endothelial growth factor and its receptor
- The Absolute Number of Peripheral Blood CD34+ Cells Predicts a Timing for Apheresis and Progenitor Cell Yield in Patients with Hematologic Malignancies and Solid Tumors
- K_ Channel Knockout Mice Crossbred with Transgenic Mice Expressing a Dominant-negative Form of Human Insulin Receptor Have Glucose Intolerance but not Diabetes
- A report of two bronchioloalveolar carcinoma cases which were rapidly improved by treatment with the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 ("Iressa"^1)
- DNA immunization with Plasmodium falciparum serine repeat antigen: regulation of humoral immune response by coinculation of cytokine expression plasmid
- Development of Functional Rat-Derived T Cells in SCID Mice Engrafted with the Fetal Thymus of LEC Rats Which Are Defective in CD4^+ T Cells
- Papillary Cystadenocarcinoma of the Prostate
- Mycoplasma ovis Detected in Free-Living Japanese Serows, Capricornis crispus
- Studies on Cancer Chemoprevention by Traditional Folk Medicines XXV.^ Inhibitory Effect of Isoliquiritigenin on Azoxymethane-Induced Murine Colon Aberrant Crypt Focus Formation and Carcinogenesis
- Evaluation of Hematological Reconstitution Potential of Autologous Peripheral Blood Progenitor Cells Cryopreserved by a Simple Controlled-Rate Freezing Method
- Role of Atp7b Gene in Spontaneous and N-Diethylnitrosamine-induced Carcinogenesis in a New Congenic Strain, WKAH.C-Atp7b Rats
- Somatoform pain disorder in a case of Klinefelter's syndrome with multiply operated lower back
- Sonic hedgehog relates to colorectal carcinogenesis
- Correlation of vascular endothelial cell proliferation with microvessel density and expression of vascular endothelial growth factor in hepatocellular carcinoma
- Promoter methylation status of DAP-kinase and RUNX3 genes in neoplastic and non-neoplastic gastric epithelia
- Soluble Fas in malignant pleural effusion and its expression in lung cancer cells
- Diffusion-Weighted Imaging in the Detection of Lymph Node Metastasis in Colorectal Cancer
- Characterization of Three cDNAs Encoding Two Isozymes of an Isoaspartyl Protein Carboxyl Methyltransferase from Human Erythroid Leukemia Cells
- Adenosarcoma of the uterine cervix presenting as a cervical polyp
- Alpha-1 Antitrypsin Deficiency with Severe Pulmonary Emphysema
- Combined Imaging with Multi-Detector Row Computed Tomography and Diffusion-Weighted Imaging in the Detection of Pancreatic Cancer
- Particle Production in Models with Helicity-0 Graviton Ghost in de Sitter Spacetime(Astrophysics and Cosmology)
- No de Sitter Invariant Vacuum in Massive Gravity Theory with Ghost(Astrophysics and Cosmology)
- Primary Carcinoid Tumor of the Ovary : MR Imaging Characteristics with Pathologic Correlation
- Volatile Components Formed by Thermal Degradation of Nondialyzable Melanoidin Prepared from a Sugar-Butylamine Reaction System
- Orthogonal Black Di-Ring Solution(Astrophysics and Relativity)
- Multifunctional interieukin-1 beta promotes metastasis of human lung cancer cells in SCID mice via enhanced expression of adhesion-, invasion- and angiogenesis-related molecules
- Inhibitory effect of soluble platelet-derived growth factor receptor beta on intraosseous growth of breast cancer cells in nude mice
- Among triple-negative breast cancers, HER2(0) breast cancer shows a strong tendency to be basal-like compared with HER2(1+) breast cancer : preliminary results
- High Susceptibility to Zymbal Gland and Intestinal Carcinogenesis in Diabetic Otsuka Long-Evans Tokushima Fatty Rats
- Invariant Range Image Multi-Pose Face Recognition Using Gradient Face, Membership Matching Score and 3-Layer Matching Search(Image Recognition, Computer Vision)
- High Susceptibility to Zymbal Gland and Intestinal Carcinogenesis in Diabetic Otsuka Long-Evans Tokushima Fatty Rats
- High Susceptibility to Zymbal Gland and Intestinal Carcinogenesis in Diabetic Otsuka Long-Evans Tokushima Fatty Rats
- Particle-to-liquid mass transfer in gas-liquid-solid fluidization.
- Establishment of a Model of Spontaneously-Running-Tokushima-Shikoku Rats with Left Atrial Thrombosis
- Flow characteristics and circular pipe flow of pulp-suspension.
- Clear Cell Adenocarcinoma Arising from Clear Cell Adenofibroma of the Ovary: Value of DWI and DCE-MRI