Telmisartan Decreases Plasma Levels of Asymmetrical Dimethyl-L-Arginine and Improves Lipid and Glucose Metabolism and Vascular Function
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概要
- 論文の詳細を見る
Telmisartan is an angiotensin II receptor blocker (ARB) and also an activator of peroxisome proliferator-activated receptor-γ (PPAR-γ). We investigated whether telmisartan improves vascular endothelial function in patients with essential hypertension with the production of endothelial nitric oxide synthase (eNOS) through PPAR-γ.Telmisartan was administered to 15 patients with essential hypertension. To assess vascular function, asymmetric dimethylarginine (ADMA), an eNOS inhibitor synthesized by endothelial cells, and the pulse-wave velocity (PWV) were measured. The serum levels of lipid, glucose, and glycohemoglobin (HbA1c) were also evaluated before and after treatment. Telmisartan therapy significantly decreased the blood pressure and total- and LDL-cholesterol levels. HbA1c was also significantly improved but not in fasting plasma glucose. The serum levels of ADMA were significantly decreased (0.48 ± 0.08 to 0.42 ± 0.05 nmol/mL; P = 0.01). PWV values were significantly decreased by telmisartan from 1,822.5 ± 352.3 to 1,661.5 ± 299.8 cm/second (P = 0.04*). Telmisartan decreased PWV presumably via the activation of PPAR-γ, suggesting that this agent improves vascular endothelial function via its pleiotropic effects, a mechanism that is different from its hypotensive effects.
- インターナショナル・ハート・ジャーナル刊行会の論文
著者
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Nakaya Yutaka
Department Of Nutrition And Metabolism Graduate School Of Nutrition And Bioscience The University Of
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Sata Masataka
Department Of Advanced Clinical Science And Therapeutics Graduate School Of Medicine University Of T
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Bando Shigenobu
Kagawa Prefectural Shiratori Hospital
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Soeki Takeshi
Kagawa Prefectural Shirotori Hospital
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Ono Yoshifumi
Kagawa Prefectural Shirotori Hospital
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Ito Susumu
Kagawa Prefectural Shirotori Hospital
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Bando Shigenobu
Kagawa Prefectural Shirotori Hospital
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Sata Masataka
Department of Cardiology, Tokushima University
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Nakaya Yutaka
Department of Cardiology, Tokushima University
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