Antioxidant and α-Amylase Inhibitory Compounds from Aerial Parts of Varthemia iphionoides Boiss
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概要
- 論文の詳細を見る
Various extracts of aerial parts of Varthemia (Varthemia iphionoides Boiss) were investigated for radical-scavenging activity, antioxidative activity, and porcine pancreas α-amylase inhibitory activity. The ethanol and water extracts showed a pronounced 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity, with inhibition of about 90% at a concentration of 100 μg/ml, and α-amylase inhibitory activity of about 70% at a concentration of 200 μg/ml by the 2-chloro-4-nitrophenyl α-maltotrioside (CNP-G3) degradation method. The ethanol extract was purified by column chromatography to give seven 3-methoxyflavones (1–7) and eudesmane sesquiterpene, selina-4,11(13)-dien-3-on-12-oic acid (8). The structures of these compounds were established by NMR, MS, and UV spectroscopy. Of 3-methoxyflavones, 5,7,4′-trihydroxy-3,6-dimethoxyflavone (1), 5,7,4′-trihydroxy-3,3′-dimethoxyflavone (2), and 5,4′-dihydroxy-3,7,3′-trimethoxyflavone (3,7,3′-tri-O-methyl-quercetin) (7) exhibited pronounced radical-scavenging activity. The antioxidative activity in the linoleic acid system was considerable in compounds 1, 2, and 5,4′-dihydroxy-3,6,7-trimethoxyflavone (4). Compounds 1, 2, 4, 5 (5,7,4′-trihydroxy-3-methoxyflavone), and 6 (5,4′-dihydroxy-3,7-dimethoxyflavone) showed markedly high inhibitory activity against porcine pancreas α-amylase. Eudesmane sesquiterpene did not show any activity.
- 社団法人 日本農芸化学会の論文
- 2007-09-23
著者
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TAKASE Mitsunori
Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd
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SHIN Kouichirou
Food Science & Technology Institute, Morinaga Milk Industry Co., Ltd.
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WAKABAYASHI Hiroyuki
Food Science & Technology Institute, Morinaga Milk Industry Co., Ltd.
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YAMAUCHI Koji
Food Science & Technology Institute, Morinaga Milk Industry Co., Ltd.
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Yamauchi Koji
Food Science & Technology Institute Morinaga Milk Industry Co. Ltd.
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Hashimoto Fumio
Department of Horticultural Science, Faculty of Agriculture, Kagoshima University
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Shin Kouichirou
Food Science & Technology Institute Morinaga Milk Industry Co. Ltd.
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Takase Mitsunori
Nutritional Science Institute Morinaga Milk Industry Co. Ltd.
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Wakabayashi Hiroyuki
Food Science & Technology Institute Morinaga Milk Industry Co. Ltd.
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Hashimoto Fumio
Department Of Horticultural Science Faculty Of Agriculture Kagoshima University
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ABE Keiko
Graduate School of Agricultural and Life Sciences, the University of Tokyo
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AL-DABBAS Maher
Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University
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KITAHARA Kanefumi
Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University
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SUGANUMA Toshihiko
Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University
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TADERA Kenjiro
Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University
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Al-dabbas Maher
Department Of Biochemical Science And Technology Faculty Of Agriculture Kagoshima University
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Matsumoto Ichiro
Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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MIYAUCHI Hirofumi
Food Science & Technology Institute, Morinaga Milk Industry Co., Ltd.
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Abe Keiko
Graduate School Of Agricultural And Life Sciences Univ. Of Tokyo
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Miyauchi Hirofumi
Food Science & Technology Institute Morinaga Milk Industry Co. Ltd.
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Abe Keiko
Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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Abe Keiko
Graduate School Of Agricultural And Life Sciences University Of Tokyo
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Takase Mitsunori
Nutritional Sci. Lab. Morinaga Milk Ind. Co. Ltd.
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Matsumoto Ichiro
Graduate School Of Agricultural And Life Sciences University Of Tokyo
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Al-Dabbas Maher
Food Science & Technology Institute, Morinaga Milk Industry Co., Ltd.
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Kitahara Kanefumi
Food Science & Technology Institute, Morinaga Milk Industry Co., Ltd.
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Suganuma Toshihiko
Food Science & Technology Institute, Morinaga Milk Industry Co., Ltd.
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