Effect of Lactobacillus brevis 119-2 isolated from Tsuda kabu red turnips on cholesterol levels in cholesterol-administered rats(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
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概要
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In a previous in vitro study, we reported that the potential mechanism of the cholesterol-lowering effect of Lactobacillus brevis 119-2 isolated from turnip Tsuda kabu was the incorporation of cholesterol to cell membrane. In this study, we analyzed serum cholesterol and hepatic gene expression of Sprague-Dawley (SD) rats kept on a cholesterol diet with or without L. brevis 119-2 for 2 weeks, to evaluate the cholesterol-lowering effect in vivo. Serum cholesterol levels were significantly reduced in SD rats kept on a diet including L. brevis 119-2 compared with that in SD rats kept on a diet without L. brevis 119-2, and both viable and dead L. brevis 119-2 induced this effect. Hepatic gene analysis by DNA microarray suggested that the potential mechanism of the cholesterol-lowering effect of L. brevis 119-2 in vivo was inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase activity by insulin induced gene (Insig) protein, and induction of catabolism of cholesterol to bile acid by Cyp7a1 (cytochrome P450 a1). In addition, we found that inclusion of L. brevis 119-2 in the diet decreased serum low density lipoprotein (LDL) cholesterol levels by inducing overexpression of the LDL receptor gene. In contrast, Lactobacillus acidophilus ATCC 43121 increased high density lipoprotein cholesterol levels by inducing overexpression of the ATP-binding cassette sub-family. A member 1 (Abca1) and Angiopoietin-like 3 (Angptl3) genes. These results suggest that L. brevis 119-2 decreases the risk of atherosclerosis by lowering serum cholesterol, ameliorating the effect of fatty liver.
- 2013-07-00
著者
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Sonomoto Kenji
Laboratory Of Industrial Biochemistry Department Of Industrial Chemistry Faculty Of Engineering Kyot
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ABE Keiko
Laboratory of Biological Function, Department of Applied Biological Chemistry, Graduate School of Ag
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KATSUBE Takuya
Shimane Institute for Industrial Technology
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Hattori Hideki
Japan Food Research Laboratories Chitose Laboratory
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Sato Hiromasa
Japan Ae Power Systems Corporation
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Ishijima Tomoko
Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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Nakai Yuji
Graduate School of Agricultural and Life Science, The University of Tokyo
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Watanabe Shinobu
Shimane Institute for Industrial Technology
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Hattori Hideki
Japan Food Research Laboratories
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Sato Hiromasa
Japan Food Research Laboratories
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Ishijima Tomoko
Graduate School of Agricultural and Life Science, The University of Tokyo
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