Characterization of a Gene Cluster of Staphylococcus warneri ISK-1 Encoding the Biosynthesis of and Immunity to the Lantibiotic, Nukacin ISK-1
スポンサーリンク
概要
- 論文の詳細を見る
We characterized a gene cluster in a plasmid designated pPI-1 of Staphylococcus warneri ISK-1 encoding the biosynthesis of and immunity to the lacticin-481 type lantibiotic, nukacin ISK-1. The DNA sequence suggested that the nukacin ISK-1 gene cluster consists of at least six genes, nukA (a structural gene), -M, -T, -F, -E, -G, and two open reading frames, ORF1 and ORF7. NukM and NukT were predicted to be involved in post-translational modification and secretion of nukacin ISK-1 respectively. NukF, -E, and -G were predicted to form a membrane complex which contributes to self-protection from nukacin ISK-1. Transcriptional analyses revealed that nukM through ORF7 comprises an operon, and that ORF1 is transcribed independently from downstream of nukA. The transcriptional levels of the nukA and nukM genes were enhanced by osmotic stress. The expression level of the nukA transcript was scarcely enhanced by nukacin ISK-1, suggesting that expression is not under the control of the autoregulatory circuit.
- 社団法人 日本農芸化学会の論文
- 2004-08-23
著者
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Aso Y
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Nakayama J
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Nakayama Jiro
Lab. Of Microbial Technol. Div. Of Microbial Sci. And Technol. Dep. Of Bioscience And Biotechnology
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Nakayama Jiro
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Nakayama Jiro
Department Of Applied Biological Chemistry Graduate School Of Agriculture And Life Sciences The Univ
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Nagao Jun-ichi
Dep. Of Functional Bioscience Section Of Infection Biology Fukuoka Dental Coll. 2-15-1 Tamura Sawara
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Nagao Jun-ichi
Department Of Functional Bioscience Section Of Infection Biology Fukuoka Dental College
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Sonomoto Kenji
Lab. Of Microbial Technol. Div. Of Microbial Sci. And Technol. Dep. Of Bioscience And Biotechnology
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Sonomoto K
(present Address)department Of Biochemical Engineering And Science Faculty Of Computer Science And S
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Sonomoto Kenji
Lab. Of Functional Food Design Dep. Of Functional Metabolic Design Bio-architecture Center Kyushu Un
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Sonomoto Kenji
Industrial Biochemistry Department Of Industrial Chemistry Faculty Of Engineering Kyoto University:(
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Sonomoto Kenji
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Sonomoto Kenji
Laboratory Of Microbial Technology Department Of Food Science And Technology Faculty Of Agriculture
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Sonomoto Kenji
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Kimura H
Kagawa Nutrition Univ. Tokyo Jpn
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SASHIHARA Toshihiro
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bios
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HIGUCHI Toshimasa
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bios
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ADACHI Asaho
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bios
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ISHIZAKI Ayaaki
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bios
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Sonomoto Kenji
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Sonomoto Kenji
Laboratory Of Industrial Biochemistry Department Of Industrial Chemistry Faculty Of Engineering Kyot
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Ishizaki Ayaaki
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Ishizaki Ayaaki
Laboratory Of Microbial Technology Department Of Bioscience And Biotechnology Faculty Of Agriculture
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Ishizaki Ayaaki
Department Of Food Science And Technology Faculty Of Agriculture Kyushu University
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Ishizaki Ayaaki
Division Of Bioscience And Biotechnology Graduate School Of Bioresource And Bioenvironmental Science
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Ishizaki Ayaaki
Laboratory Of Microbial Science And Technology Division Of Bioscience And Biotechnology Graduate Sch
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Ishizaki Ayaaki
Laboratory Of Microbial Technology Department Of Food Science And Technology Faculty Of Agriculture
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Sonomoto Kenji
Laboratory Of Microbial Technology Department Of Bioscience And Biotechnology Faculty Of Agriculture
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Aso Yuji
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Ishizaki A
Laboratory Of Microbial Technology Department Of Bioscience And Biotechnology Faculty Of Agriculture
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Adachi A
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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NAGAO Jun-ichi
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bios
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KANEMASA Youhei
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bios
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KOGA Hanako
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bios
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Koga H
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Kanemasa Youhei
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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HASHIMOTO Taku
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bios
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NOMIYAMA Harumi
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bios
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Hashimoto Taku
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Kimura Hiromi
Laboratory Of Microbial Technology Department Of Food Science And Technology Faculty Ofagriculture K
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Nomiyama Harumi
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Sashihara Toshihiro
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Higuchi T
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Nagao Jun-ichi
Laboratory of Microbial Technology, Division of Applied Molecular Microbiology and Biomass Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
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