A Novel Type of Immunity Protein, NukH, for the Lantibiotic Nukacin ISK-1 Produced by Staphylococcus warneri ISK-1
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概要
- 論文の詳細を見る
Staphylococcus warneri ISK-1 produces a lantibiotic, nukacin ISK-1. The nukacin ISK-1 gene cluster consists of at least six genes, nukA, -M, -T, -F, -E, and -G, and two open reading frames, ORF1 and ORF7 (designated nukH). Sequence comparisons suggested that NukF, -E, -G, and -H contribute to immunity to nukacin ISK-1. We investigated the immunity levels of recombinant Lactococcus lactis expressing nukFEG and nukH against nukacin ISK-1. The co-expression of nukFEG and nukH resulted in a high degree of immunity. The expression of either nukFEG or nukH conferred partial immunity against nukacin ISK-1. These results suggest that NukH contributes cooperatively to self-protection with NukFEG. The nukacin ISK-1 immunity system might function against another lantibiotic, lacticin 481. Western blot analysis showed that NukH expressed in Staphylococcus carnosus was localized in the membrane. Peptide release/bind assays indicated that the recombinant L. lactis expressing nukH interacted with nukacin ISK-1 and lacticin 481 but not with nisin A. These findings suggest that NukH contributes cooperatively to host immunity as a novel type of lantibiotic-binding immunity protein with NukFEG.
- 社団法人 日本農芸化学会の論文
- 2005-07-23
著者
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Aso Y
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Nakayama J
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Nakayama Jiro
Lab. Of Microbial Technol. Div. Of Microbial Sci. And Technol. Dep. Of Bioscience And Biotechnology
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Nakayama Jiro
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Nakayama Jiro
Department Of Applied Biological Chemistry Graduate School Of Agriculture And Life Sciences The Univ
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Nagao Jun-ichi
Dep. Of Functional Bioscience Section Of Infection Biology Fukuoka Dental Coll. 2-15-1 Tamura Sawara
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Nagao Jun-ichi
Department Of Functional Bioscience Section Of Infection Biology Fukuoka Dental College
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Sonomoto Kenji
Lab. Of Microbial Technol. Div. Of Microbial Sci. And Technol. Dep. Of Bioscience And Biotechnology
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Sonomoto K
(present Address)department Of Biochemical Engineering And Science Faculty Of Computer Science And S
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Sonomoto Kenji
Lab. Of Functional Food Design Dep. Of Functional Metabolic Design Bio-architecture Center Kyushu Un
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Sonomoto Kenji
Industrial Biochemistry Department Of Industrial Chemistry Faculty Of Engineering Kyoto University:(
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Sonomoto Kenji
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Sonomoto Kenji
Laboratory Of Microbial Technology Department Of Food Science And Technology Faculty Of Agriculture
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Sonomoto Kenji
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Kimura H
Kagawa Nutrition Univ. Tokyo Jpn
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SASHIHARA Toshihiro
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bios
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Sonomoto Kenji
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Sonomoto Kenji
Laboratory Of Industrial Biochemistry Department Of Industrial Chemistry Faculty Of Engineering Kyot
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Sonomoto Kenji
Laboratory Of Microbial Technology Department Of Bioscience And Biotechnology Faculty Of Agriculture
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Aso Yuji
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Thi Bich
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Shioya Kouki
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bios
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OKUDA Ken-ichi
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bios
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NAGAO Jun-ichi
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bios
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KANEMASA Youhei
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bios
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KOGA Hanako
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bios
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Koga H
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Kanemasa Youhei
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Kimura Hiromi
Laboratory Of Microbial Technology Department Of Food Science And Technology Faculty Ofagriculture K
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Shioya Kouki
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Okuda Ken-ichi
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Sashihara Toshihiro
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Sonomoto Kenji
Lab. Of Functional Food Design Dep. Of Functional Metabolic Design Bio-architecture Center Kyushu Un
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Nagao Jun-ichi
Laboratory of Microbial Technology, Division of Applied Molecular Microbiology and Biomass Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
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