Dietary Tocotrienol Reduces UVB-Induced Skin Damage and Sesamin Enhances Tocotrienol Effects in Hairless Mice

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We have previously reported that substantial amounts of tocotrienols were present in the skin of animals fed a diet containing a tocopherols and tocotrienols rich fraction (T-mix) extracted from palm oil, and further, that sesame lignans enhanced tocotrienol levels in the skin. The present studies were undertaken to determine whether dietary tocotrienols and those with sesamin could protect the skin from damage induced by UVB irradiation in hairless mice fed four diets: a vitamin E-free diet, a 50mg/kg α-tocopherol diet, a 229mg/kg T-mix (with 50mg α-tocopherol) diet and a 229mg/kg T-mix with 2g/kg sesamin diet. In Experiment 1, mice were fed the diets for 6wk, and half of the mice were exposed to 180mJ/cm^2 of UVB light once daily for 7 d. After the intensity of sunburn was scored, vitamin E and thiobarbituric acid reactive substances (TBARS) concentrations in the skin and liver were determined. In Experiment 2, hairless mice were initiated with a single application of 7, 12-dimethylbenz[a]anthracene (DMBA), then 1 wk later mice were fed the experimental diets and subjected to 180mJ/cm^2 UVB irradiation twice weekly for 20 wk. Tumor incidences were counted once a week. Tocotrienols were detected in the skin of mice fed T-mix, but their concentrations were significantly lower than for α-tocopherol. Sesamin elevated tocotrienol contents in the skin. In spite of the high α-tocopherol contents, the effects of α-tocopherol on sunburn and incidence of tumor were slight. T-mix fed groups reduced the extent of sunburn and incidence of tumor, and further reduction of sunburn and incidence of tumor were observed in the T-mix with sesamin group. These results suggest that dietary tocotrienols protect the skin more strongly than α-tocopherol against damage induced by UVB and sesamin enhances tocotrienol effects.

Dietary Tocotrienol Reduces UVB-Induced Skin Damage and Sesamin Enhances Tocotrienol Effects in Hairless Mice

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