Dietary Sesame Seed and Its Lignan Increase Both Ascorbic Acid Concentration in Some Tissues and Urinary Excretion by Stimulating Biosynthesis in Rats
スポンサーリンク
概要
- 論文の詳細を見る
We previously showed that the intake of sesamin, a major lignan in sesame seed, decreased lipid peroxidation and elevated tocopherol concentration in rat tissues. In this study, we examined the effect of dietary sesame seed and sesamin on the ascorbic acid concentration in rat tissues. Rats (4-wk-old) were fed either a vitamin E-free diet, or a diet containing 50mg γ-tocopherol/kg, one containing 2g sesamin/kg, one containing 50mg γ-tocopherol/kg and 2g sesamin/kg, or one containing 200g sesame seed/kg for 28d. The dietary sesamin and sesame seed elevated ascorbic acid concentrations in the liver and kidney, and increased urinary excretion in those Wistar rats. The dietary sesamin also elevated the hepatic mRNA levels of cytochrome P450 (CYP) 2B, and UDP-glucuronosyltransferase (UGT) 1A and 2B. In contrast, neither the sesamin nor the sesame seed affected the liver concentration of ascorbic acid in ODS rats with a hereditary defect in ascorbic acid synthesis, though the dietary sesame seed elevated the UGT1A and 2B mRNA levels in the liver. In addition, the sesame seed elevated the γ-tocopherol concentration in the various ODS rat tissues and the ascorbic acid concentrations in the kidney, heart and lung, while reducing the thiobarbituric acid reactive substance concentration in the heart and kidney. These results suggest that dietary sesame seed and its lignan stimulate ascorbic acid synthesis as a result of the induction of UGT1A and the 2B-mediated metabolism of sesame lignan in rats. The data of ODS rat studies also suggest that dietary sesame seed enhances antioxidative activity in the tissues by elevating the levels of two antioxidative vitamins, vitamin C and E.
- 日本ビタミン学会の論文
著者
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山下 かなへ
椙山女学園大学大学院生活科学部
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Ichikawa Tomio
Department Of Food Science And Nutrition School Of Human Life And Environmental Sciences Mukogawa Wo
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Horio Fumihiko
Graduate School Of Bioagricultural Sciences Nagoya University
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山下 かなへ
椙山女学園大生活科学食品栄養学
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YAMASHITA Kanae
Department of Food and Nutrition, Sugiyama Jogakuen University
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Yamashita Kanae
Departmen T Of Physiology Nagoya City University Medical School
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IKEDA Saiko
Department of Anatomy, jaunted University Scool of Medicine
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Ikeda Saiko
Department Of Anatomy Jaunted University Scool Of Medicine
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ABE Chisato
Department of Nutritional Sciences, Nagoya University of Arts and Sciences
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UCHIDA Tomono
Department of Nutritional Sciences, Nagoya University of Arts and Sciences
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Ichikawa Tomio
Department Of Nutritional Sciences Nagoya University Of Arts And Sciences
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Ikeda Saiko
Department Of Nutritional Sciences Nagoya University Of Arts And Sciences
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Abe Chisato
Department Of Food And Nutrition Tsu City College
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Uchida Tomono
Department Of Nutritional Sciences Nagoya University Of Arts And Sciences
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Uchida Tomono
Department Of Nutritional Sciences Nagoya University Of Arts And Science
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ICHIKAWA Tomio
Department of Applied Food Research, National Institute of Health and Nutrition
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