ATPase Activity and Ca2+ Interaction of Myofibrils and Sarcoplasmic Reticulum Isolated from the Hearts of Spontaneously Hypertensive Rats

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概要

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• ATPase activity of myofibrils and Ca2+ binding ability of sarcoplasmic reticulum isolated from the hearts of spontaneously hypertensive rats (OkamotoAoki strain, SHR) and normotensive Wistar rats (NR) were measured. Myofibrils isolated from both the hearts of SHR and NR showed essentially the same activity either in the absence or presence of Ca2+. On the other hand, Ca2+ activated ATPase activity of relaxed preparation of myofibrils from SHR was significantly lower than that from NRThe maximum Ca2+ binding capacity of sarcoplasmic reticulum (SR) from SHR (8.80±0.33nmoles/mg) was significantly lower than that from NR (11.95±0.55). Also, SR from SHR had significantly elevated Ca2+ activated ATPase activity (0.171±0.009μmoles/mg/min) compared with that of NR (0.100±0.009). Values were expressed as mean±s.e.m.Reduction of Ca2+ binding capacity of SR may result in increase of intracellular free Ca2+ concentration which probably be one of the important factor for muscle contraction. If the abnormal intracellular distribution of Ca2+ is associated with the smooth muscle of cardiovascular system, it would cause the increase of vascular resistance resulting in hypertension.

• International Heart Journal刊行会の論文

著者

• HOTTA Ken

  Department of Physiology, Nagoya City University Medical School

• Hotta Ken

  Departmen T Of Physiology Nagoya City University Medical School

• YAMASHITA Kanae

  Department of Food and Nutrition, Sugiyama Jogakuen University

• Aoki Kyuzo

  2nd Department Of Medicine School Of Medicine Nagoya City University

• Aoki Kyuzo

  Department Of Medicine Nagoya City University Medical School

• Yamashita Kanae

  Departmen T Of Physiology Nagoya City University Medical School

• Aoki Kyuzo

  The Second Department Of Medicine Nagoya City University Medical School

• IKEDA Nobuko

  Department of Medicine, School of Medicine, Nagoya City University

• Aoki K.yozo

  Department Of Medicine Nagoya City University Medical School

• Aoki Kyuzo

  The Second Department Of Medicine Nagoya City University Medical School Nagoya Japan

• Ikeda Nobuko

  Department Of Medicine And Department Of Physiology Nagoya City University School Of Medicine

• Aoki Kyozo

  2nd Dept. Of Med Nagoya City Univ. Med. Sch.

• YAMASHITA Kanae

  Department of Physiology, School of Medicine, Nagoya City University

• HOTTA Ken

  Department of Physiology, School of Medicine, Nagoya City University

• Aoki Kyuzo

  Department of 2nd Internal Medicine, Nagoya City University Medical School

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