Contraction and Ca2+-uptake of aortic smooth muscle from Spontaneously Hypertensive Rats
スポンサーリンク
概要
- 論文の詳細を見る
To find out the cellular role to develop hypertension, the characteristics of membrane systems in vascular smooth muscle to regulate the intracellular Ca2+ level were investigated. The differences between Spontaneously Hypertensive Rats (SHR, Okamoto-Aoki) and Kyoto Wistar normotensive rats (KNR) in contractile response and Ca2+ influx in the presence and absence of Ca2+-antagonist (verapamil) were analyzed. (i) Aortic strip could induce rapid tension by serotonin (5HT) and noradrenaline (NA) in Ca2+-free medium but not by K+. (ii) SHR aortic strips developed larger tension than KNR in normal physiological salt solution (PSS). (iii) SHR aortic strips developed tension was more inhibited by verapamil than KNR. (iv) Ca2+ influx in aortic tissue from SHR was smaller than that from KNR, and verapamil inhibited Ca2+ uptake in SHR more greatly than in KNR. These findings suggest that the membrane systems of SHR aortic muscle have an abnormal function
- International Heart Journal刊行会の論文
著者
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Hotta Ken
1st Department Of Physiology Nagoya City University Medical School
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Mochizuki Akihiro
2nd Dept. of Int. Med., and 1st Dept. of Physiol, Nagoya City Univ. Med. School
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Yamamoto Yoshimichi
2nd Dept. of Int. Med., and 1st Dept. of Physiol, Nagoya City Univ. Med. School
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Aoki Kyuzo
2nd Department Of Medicine School Of Medicine Nagoya City University
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Hotta Ken
1st Dept. of Physiol, Nagoya City Univ. Med. School, Nagoya
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Kondo Schuta
2nd Dept. of Int. Med, Nagoya City Univ. Med. School
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Mizuno Takako
1st Dept. of Physiol, Nagoya City Univ. Med. School, Nagoya
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AOKI Kyuzo
2nd Department of Internal Medicine, Nagoya City University Medical School
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Mochizuki Akihiro
2nd Dept. of Int. Med, Nagoya City Univ. Med. School
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Mochizuki Akihiro
2nd Dept of Med and 1st Dept of Physiol, Nagoya City Univ Med Sch.
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Yamamoto Yoshimichi
2nd Dept. of Int. Med, Nagoya City Univ. Med. School
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Yamamoto Yoshimichi
2nd Dept of Med and 1st Dept of Physiol, Nagoya City Univ Med Sch.
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Aoki Kyuzo
2nd Dept. of Int. Med, Nagoya City Univ. Med. School
関連論文
- SPECIFICITY OF TENSION DEVELOPMENT OF AORTA FROM SPONTANEOUSLY HYPERTENSIVE RAT : Hypertension I : Ist Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- DISORDERS OF AUTONOMIC NERVOUS CARDIAC CONTROL IN JUVENILE HYPERTENSION : IIIrd Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- VASCULAR SMOOTH MUSCLE CONTRACTION IN HYPERTENSION : PROCEEDINGS OF THE 38TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- INCREASED RESPONSE OF BLOOD PRESSURE TO REST AND HANDGRIP IN SUBJECTS WITH ESSENTIAL HYPERTENSION
- HEMODYNAMIC CHANGES TO STATIC EXERCISE IN PATIENTS WITH ESSENTIAL HYPERTENSION : THE EFFECT OF NIFEDIPINE : Hypertension (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
- -498- ABNORMALITY OF ARTERIAL CONTRACTION IN SPONTANEOUSLY HYPERTENSIVE RATS
- CALCIUM UPTAKE, RELEASE AND Mg-ATPase ACTIVITY OF SARCOPLASMIC RETICULUM FROM ARTERIAL SMOOTH MUSCLE
- PRESSOR RESPONSES TO VASOACTIVE SUBSTANCES WITH AND WITHOUT CALCIUM ANTAGONIST IN SUBJECTS WITH ESSENTIAL HYPERTENSION OR NORMOTENSION : Hypertension (III) : III : 48 Annual Scientific Meeting, Japanese Circulation Society
- NIFEDIPINE AND PRAZOSIN INHIBIT THE EPINEPHRINE-AND PHENYLEPHRINE-INDUCED RISE IN BLOOD PRESSURE IN SUBJECTS WITH NORMOTENSION OR HYPERTENSION : Sympathetic Function : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- CALCIUM UPTAKE BY SUB-CELLULAR MEMBRANES FROM VASCULAR SMOOTH MUSCLE OF SPONTANEOUSLY HYPERTENSIVE RATS
- Cardiovascular Contraction in Spontaneously Hytertensive Rat--Ca2+ Interaction of Myofibrils and Subcellular Membrane of Heart and Arterial Smooth Muscle (3 Conference of Pathogenesis of Hypertension)
- Hypotensive Action and Increased Plasma Renin Activity by Ca2+ Antagonist (Nifedipine) in Hypertensive Patients
- Ca BINDING AND RELEASE BY MICROSOMAL FARCTION FROM RAT AORTA : EFFECTS OF NORADRENALINE AND NaCl ON Ca RELEASE
- ATPase Activity and Ca2+ Interaction of Myofibrils and Sarcoplasmic Reticulum Isolated from the Hearts of Spontaneously Hypertensive Rats
- ADRENAL CORTEX, NO MEDULLA, CONTRIBUTING TO PERSIST HYPERTENSION : (Part II)
- Hypertension Persisted Following Bilateral Adrenal Medullectomy
- CARDIAC MYOFIBRILLAR ATPase ACTIVITY AND CALCIUM BINDING OF SARCOPLASMIC RETICULUM IN SPONTANEOUSLY HYPERTENSIVE RAT
- CARDIAC MYOFIBRILLAR ATPase ACTIVITY AND CALCIUM BINDING OF CARDIAC MICROSOMA IN THE SPONTANEOUSLY HYPERTENSIVE RAT : Proceedlngs of the 35th Annual Meetlng of the Japanese Circulation Society (part I)
- CARDIAC MYOFIBRILLAR ATPase ACTIVITY IN THE SPONTANEOUSLY HYPERTENSIVE RAT
- SERUM DOPAMINE-β-HYDROXYLASE ACTIVITY IN ESSENTIAL HYPERTENSION AND IN CHRONIC RENAL FAILURE WITH HYPERTENSION
- STUDY ON ELEVATION OF SERUM CREATINE PHOSPHOKINASE ACTIVITY INDUCED BY EXERCISE
- KINETIC STUDY OF BINDING ATP AND ITP TO MYOFIBRILS
- CALCIUM DEPENDENT SYNTHESIS OF ATP BY SARCOPLASMIC RETICULUM
- Comparison of inhibitory effects of calcium channel blockers and that of a calmodulin antagonist in strips of mesenteric arteries from spontaneously hypertensive and normotensive rats.
- Possible Relationship between Receptor Reserves and Effects of Nifedipine on α1 -Adrenoceptor-Mediated Contractile Responses in Spontaneously Hypertensive Rats
- Contraction and Ca2+-uptake of aortic smooth muscle from Spontaneously Hypertensive Rats
- Tension Development of Aorta from SHR
- Diminished β1-Adrenoceptor Mediated Relaxation in the Arteries of SHR