Hypotensive Action and Increased Plasma Renin Activity by Ca2+ Antagonist (Nifedipine) in Hypertensive Patients
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概要
- 論文の詳細を見る
The Ca2+ antagonistic coronary vasodilator, Nifedipine, was sublingually administered by a dose of 30mg to 19 patients with hypertension.Blood pressure of patients with essential hypertension (n=14) decreased from 177±24 to 123±13mmHg systolic and from 108±12 to 80±11mmHg diastolic (mean±SD) (p<0.01). Heart rate increased significantly from 73±11 to 85±10 beats/min (p<0.01). Plasma renin activity (PRA) increased significantly from 0.73±0.62 to 1.50±1.02ng/ml/h (p<0.05). The same tendency was observed in malignant and renovascular hypertension. In primary aldosteronism (n=2), blood pressure decreased but PRA did not increase.Hypotensive action and increased plasma renin activity by Ca2+ antagonist, Nifedipine, were clearly demonstrated in patients with hypertension.
- International Heart Journal刊行会の論文
著者
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Hotta Ken
First Department Of Physiology Nagoya City University Medical School
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Aoki Kyuzo
2nd Department Of Medicine School Of Medicine Nagoya City University
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Aoki Kyuzo
Department Of Medicine Nagoya City University Medical School
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Aoki Kyuzo
The Second Department Of Medicine Nagoya City University Medical School
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AOKI Kyuzo
Second Department of Medicine, Nagoya City University Medical School
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YOSHIDA Tadashi
Second Department of Medicine, Nagoya City University Medical School
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KATO Setsuko
Second Department of Medicine, Nagoya City University Medical School
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TAZUMI Kazuhiro
Second Department of Medicine, Nagoya City University Medical School
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SATO Iwao
Second Department of Medicine, Nagoya City University Medical School
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TAKIKAWA Kiyoharu
Second Department of Medicine, Nagoya City University Medical School
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Aoki K.yozo
Department Of Medicine Nagoya City University Medical School
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Aoki Kyuzo
The Second Department Of Medicine Nagoya City University Medical School Nagoya Japan
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Aoki Kyozo
2nd Dept. Of Med Nagoya City Univ. Med. Sch.
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Hotta Ken
First Department of Physiology, Nagoya City University Medical School
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SATO Iwao
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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AOKI Kyuzo
Second Department of Internal Medicine, Nagoya City University Medical School
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