Hypotensive effects of a calcium antagonist, bepridil, in patients with essential hypertension.

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概要

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• The short and long term hypotensive effects of oral administration of bepridil were investigated in 26 patients with essential hypertension. A new calcium antagonist, bepridil inhibits the ion influx through sodium and potassium channels as well as calcium channels by directly affecting these channels. The drug (150mg) rapidly decreased blood pressure (BP) from 157±12/97±8 to 137±10/86±8mmHg (mean±SD, p<0.01) and heart rate (HR) from 64±5 to 58±4 beats/min (p<0.01) (n=6) in 2 hours. Long term administration of 150mg bepridil daily (50mg t.d.s.) decreased BP from 169±6/104±8 to 143±14/83±7mmHg (p<0.001), but did not change HR (66±4 and 67±5 beats/min, before and after administration) (n=9). Bepridil at 300mg (100mg t.d.s.) decreased BP from 172±15/105±8 to 146±11/88±4mmHg (p<0.001) and HR from 76±11 to 70±8 beats/min (p<0.01) (n=9). No side effects were observed. In conclusion, the hypotensive and negative chronotropic actions of bepridil are beneficial in the short and long term treatment of essential hypertension.

• International Heart Journal刊行会の論文

著者

• AOKI Kyuzo

  Second Department of Internal Medicine, Nagoya City University Medical School

• SATO Koichi

  Second Department of Internal Medicine, Nagoya City University Medical School

関連論文

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• Decrease in blood pressure and increase in total peripheral vascular resistance in supine resting subjects with normotension or essential hypertension.
• Hypotensive effects of a calcium antagonist, bepridil, in patients with essential hypertension.

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