Decrease in blood pressure and increase in total peripheral vascular resistance in supine resting subjects with normotension or essential hypertension.

概要

論文の詳細を見る
Hemodynamic changes in the supine resting position were investigated in 70 male subjects, consisting of 15 healthy volunteers with normotension (blood pressure of 113±7/70±5mmHg, M±SD), 25 patients with borderline essential hypertension (143±12/90±6mmHg) and 30 patients with established essential hypertension (166±13/108±6mmHg). The supine position reduced blood pressure, heart rate, stroke volume and cardiac output (p<0.001), but increased total peripheral vascular resistance (p<0.001). The decrease in systolic blood pressure (p<0.01), stroke volume (p<0.05) and cardiac output (p<0.05), and the increase in total peripheral vascular resistance (p<0.01) were significantly greater in the borderline and established essential hypertensive groups than in the normotensive group. The results demonstrated that the decrease in blood pressure was due to a reduction in both heart rate and stroke volume, and that the decrease in stroke volume and increase in total peripheral vascular resistance seen in the supine position were greater in the hypertensive groups than in the normotensive group. These hyperresponses may contribute to the development and persistence of high blood pressure in patients with essential hypertension.
International Heart Journal刊行会の論文