Cardiovascular Contraction in Spontaneously Hytertensive Rat--Ca2+ Interaction of Myofibrils and Subcellular Membrane of Heart and Arterial Smooth Muscle (3 Conference of Pathogenesis of Hypertension<特集>)
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概要
- 論文の詳細を見る
Cardiac myofibrils isolated from the hearts of Okamoto-Aoki hypertensive rat (SHR) and normotensive Wistar rat (NR) showed essentially the same ATPase activity either in the absence or presence of Ca^<2+>. On the other hand, Ca^<2+> activated ATPase activity of relaxed preparation of cardiac myofibrils from SHR was significantly lower than that from NR. ATPase activity and Ca^<2+> binding ability of cardiac sarcoplasmic reticulum (cardiac SR) and arterial subcellular membrane (arterial SR) isolated from SHR and NR were measured. The maximum Ca^<2+> binding capacity of cardiac SR from SHR (8.80±0.33 nmoles/mg) was significantly lower than that from NR (11.95±0.55). Also, cardiac SR from SHR had significantly elevated Ca^<2+> activated ATPase activity (0.171±0.009 μmoles/mg/min) compared with that of NR (0.100±0.009). And, the maximum Ca^<2+> binding capacity of arterial SR from SHR (23.55±0.72 nmoles/mg) was significantly lower than that from NR (39.35±4.89). ATPase activity of arterial SR from SHR (2.94±0.18 μmoles/mg/min) was significantly elevated compared with that of NR (2.22±0.14). Reduction of Ca^<2+> binding capacity of both cardiac and arterial SR may result in increase of intracellular free Ca^<2+> concentration which probably be one of the important factor for increase of muscular tone. If this abnormal intracellular distribution of Ca^<2+> is associated with the vascular smooth muscle, it would cause the increase of vascular resistance resulting in hypertension.
- 社団法人日本循環器学会の論文
- 1975-01-20
著者
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Ikeda Nobuo
Department of Cardiology, Chunichi Hospital
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Ikeda Nobuo
Department Of Cardiology Chunichi Hospital
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Ikeda Nobuo
Departments Of Medicine And Physiologyt Schcol Of Medicine Nagoya City University
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SATO Iwao
Department of Surgery, Nanbugo General Hospital
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HOTTA Ken
Department of Physiology, Nagoya City University Medical School
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Hotta Ken
First Department Of Physiology Nagoya City University Medical School
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Hotta Ken
Departmen T Of Physiology Nagoya City University Medical School
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Sato Iwao
Department Of Surgery Nanbugo General Hospital
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YAMASHITA Kanae
Department of Food and Nutrition, Sugiyama Jogakuen University
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Sato Iwao
Departments Of Medicine And Physiologyt Schcol Of Medicine Nagoya City University
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Hotta Ken
Departments Of Medicine And Physiologyt Schcol Of Medicine Nagoya City University
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Aoki Kyuzo
2nd Department Of Medicine School Of Medicine Nagoya City University
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Aoki Kyuzo
Department Of Medicine Nagoya City University Medical School
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Tazumi Kazuhiro
2nd Department Of Medicine School Of Medicine Nagoya City University
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Yamashita Kanae
Departments Of Medicine And Physiologyt Schcol Of Medicine Nagoya City University
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Yamashita Kanae
Departmen T Of Physiology Nagoya City University Medical School
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AOKI KYUZO
The 2nd Department of Internal Medicine and 1st Department of Physiology
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Tazumi Kazuhiro
Departments Of Medicine And Physiologyt Schcol Ofmedicine Nagoya City University
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Aoki Kyuzo
The Second Department Of Medicine Nagoya City University Medical School
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AOKI K.YOZO
Departments of Medicine and Physiologyt Schcol of Medicine, Nagoya City University
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Aoki K.yozo
Department Of Medicine Nagoya City University Medical School
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Aoki Kyuzo
The Second Department Of Medicine Nagoya City University Medical School Nagoya Japan
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Sato Iwao
Department Of Anatomy School Of Dentistry At Tokyo Nippon Dental University
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Ikeda Nobuko
Department Of Medicine And Department Of Physiology Nagoya City University School Of Medicine
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Aoki Kyozo
2nd Dept. Of Med Nagoya City Univ. Med. Sch.
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Hotta Ken
Department Of Medicine And Department Of Physiology Nagoya City University School Of Medicine
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Ikeda Nobuo
Department Of Cardiology
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IKEDA Nobuo
Department of Applied Chemistry, Faculty of Engineering, Nagoya University
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TAZUMI Kazuhiro
Departments of Medicine and Physiology, School of Medicine, Nagoya City University
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TAZUMI Kazuhiro
Departments of Medicine and Physiology, Nagoya City University, School of Medicine
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Aoki Kyuzo
Department of 2nd Internal Medicine, Nagoya City University Medical School
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