Mechanism of Cerebral Vasospasm : Contractile Proteins in Smooth Muscle of Bovine Cerebral Artery
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概要
- 論文の詳細を見る
Understanding of the pathogenesis of cerebral vasospasm requires basic study of the contraction mechanism of cerebral arteries. In this study, the morphological and biochemical properties of actomyosin from bovine cerebral arteries were examined. Arrays of thick and thin filaments were clearly seen on electron micrographs of a cross section of a muscle strip stretched to 1.5 times its normal length in Krebs-Ringer solution. The diameters of the thick and thin filaments were 110.0±19.9 Å and 51.0±8.0 Å, respectively. The average ratio of thick to thin filaments was about 1:15 to 1:16. The gel pattern of Ca^<2+>-sensitive actomyosin extracted from bovine cerebral arteries revealed the presence of myosin, actin, and tropomyosin, but not skeletal troponin. The Mg-ATPase activity of actomyosin was greatly enhanced in the presence of Ca^<2+>. Rapid superprecipitation occurred after the clearing phase, when 1 mM Mg-ATP was added to a suspension of actomyosin with 10^<-5> M Ca^<2+>. This superprecipitation did not occur with a lower Ca^<2+> concentration of 10^<-8> M. Intracellular free Ca^<2+> appears to play a crucial role in the regulation of contraction and relaxation of cerebfal arterial smooth muscle.
- 日本脳神経外科学会の論文
- 1989-07-15
著者
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TAKAGI Takuji
Departments of Neurosurgery, Nagoya City Higashi General Hospital
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Takagi Takuji
Department Of Neurosurgery Nagoya City Higashi General Hospital
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TAN En-Chow
Department of Neurosurgery, Nagoya City Higashi General Hospital
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ITOH Nobuo
Department of Pathology, Sinshu University Medical School
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FUKUOKA Hidekazu
Department of Neurosurgery, Nagoya City Higashi General Hospital
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HOTTA Ken
Department of Physiology, Nagoya City University Medical School
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Hotta Ken
Departmen T Of Physiology Nagoya City University Medical School
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Fukuoka Hidekazu
Department Of Neurosurgery Nagoya City Higashi General Hospital
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Fukuoka Hidekazu
Department Of Mechanical Engineering Faculty Of Engineering Science Osaka University
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Itoh Nobuo
Department Of Physiology Nagoya City University Medical School
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Tan En-chow
Department Of Neurosurgery Nagoya City Higashi General Hospital
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Tan En-chow
Department Of Neurosurgery Nagoya City University Medical School
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Itoh Nobuo
Department Of Electronics Colledge Of Engineering University Of Osaka Prefecture
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Itoh Nobuo
Department Of Clinical Pathology Iida Municipal Hospital
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