Inhibition of Expression of Ornithine Decarboxylase by c-myc Antisense Oligonucleotide at the Promotion Stage of Lung Tumorigenesis in Mice
スポンサーリンク
概要
- 論文の詳細を見る
Regulation of ornithine decarboxylase (ODC) expression at a promotion stage of lung carcinogenesis is a key clue to suppress the cancer. In this study, we investigated that the ODC induction at the promotion stage of lung carcinogenesis in mice could be inhibited through the suppression of the expression of c-myc, a transcription factor for ODC. The treatment with c-myc antisense oligonucleotide decreased the carcinogen-elevated level of pulmonary ODC protein at the promotion stage, but the sense oligonucleotide had no influence on the level. Overall, it is possible that the induction of ODC in the carcinogenic process of lung is regulated at its transcriptional level.
- 社団法人 日本薬理学会の論文
- 2001-09-01
著者
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YANO Yoshihisa
Second Department of Biochemistry, Osaka City University Medical School
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OTANI Shuzo
Second Department of Biochemistry, Osaka City University Medical School
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Ichikawa Tomio
Department Of Food Science And Nutrition School Of Human Life And Environmental Sciences Mukogawa Wo
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Ichikawa Tomio
Nat1.inst.health & Nutrition
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HAGIWARA Kiyokazu
Department of Food Science Research for Health, National Institute of Health and Nutrition
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YANO Tomohiro
Division of Applied Food Research, National Institute of Health and Nutrition
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Yano Y
Department Of Biochemistry Osaka City University Medical School
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Yano Yoshihisa
Second Department Of Biochemistry Osaka City University Medical School
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Yano Yoshihisa
Second Biochemistry Osaka City University Medical School
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Otani S
Department Of Biochemistry Osaka City University Medical School
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Otani Shuzo
Second Department Of Biochemistry Osaka City University Medical School
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Horikawa Saburo
Department Of Pathological Biochemistry Medical Research Institute Tokyo Medical And Dental Universi
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Ichikawa T
Department Of Life Environmental Sciences Mukogawa Women's College
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SATOH Haruna
Division of Applied Food Research, National Institute of Health and Nutrition
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HAGIWARA Kiyokazu
Division of Applied Food Research, National Institute of Health and Nutrition
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Ichikawa Tomio
Department Of Molecular Neuropathology Brain Research Institute Niigata University
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Hagiwara Kiyokazu
Department Of Food Science Research For Health National Institute Of Health And Nutrition
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Hagiwara Kiyokazu
Division Of Applied Food National Institute Of Health And Nutrition
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Otani S
Osaka City Univ. Medical School Osaka Jpn
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Satoh Haruna
Department Of Food Science Research For Health National Institute Of Health And Nutrition
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Yano Tomohiro
Department Of Food Science Research For Health National Institute Of Health And Nutrition
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Yano Tomohiro
Division Of Applied Food National Institute Of Health And Nutrition
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ICHIKAWA Tomio
Department of Applied Food Research, National Institute of Health and Nutrition
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