Cytotoxic Effect of the Her-2/Her-1 Inhibitor PKI-166 on Renal Cancer Cells Expressing the Connexin 32 Gene
スポンサーリンク
概要
- 論文の詳細を見る
We have reported that connexin (Cx) 32 acts as a tumor suppressor gene in renal cancer cells partly due to Her-2 inactivation. Here, we determined if a Her-2/Her-1 inhibitor (PKI-166) can enhance the tumor-suppressive effect of Cx32 in Caki-2 cells from human renal cell carcinoma. The expression of Cx32 in Caki-2 cells was required for PKI-166-induced cytotoxic effect at lower doses. The cyctotoxicity was dependent on the occurrence of apoptosis and partly mediated by Cx32-driven gap junction intercellular communications. These results suggest that PKI-166 further supports the tumor-suppressive effect of the Cx32 gene in renal cancer cells through the induction of apoptosis.
- 社団法人 日本薬理学会の論文
- 2005-02-20
著者
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UENO Koichi
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, C
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Sato Hiromi
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, C
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Yamasaki Hiroshi
Department of Rehabilitation of Medicine
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YANO Tomohiro
Department of Nephrology and Rheumatology, Kinki University Faculty of Medicine
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Ueno K
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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NEGISHI Etsuko
Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chi
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Sato Hiromi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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HAGIWARA Hiromi
Project for Complementary Factors, National Institute of Health and Nutrition
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YAMASAKI Hiroshi
Faculty of Sciences and Technology, Kwansei Gakuin University
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FUJIMOTO Eriko
Department of Geriatric Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Chiba Uni
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HAGIWARA Kiyokazu
Department of Food Science Research for Health, National Institute of Health and Nutrition
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SHIRAI Sumiko
Department of Food Science Research for Health, National Institute of Health and Nutrition
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FUKUMOTO Keiko
Department of Food Science Research for Health, National Institute of Health and Nutrition
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HAGIWARA Hiromi
Department of Food Science Research for Health, National Institute of Health and Nutrition
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Shirai Sumiko
Department Of Food Science Research For Health National Institute Of Health And Nutrition
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Fukumoto Keiko
Department Of Food Science Research For Health National Institute Of Health And Nutrition
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Ueno K
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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Ueno Koichi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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Hagiwara Kiyokazu
Department Of Food Science Research For Health National Institute Of Health And Nutrition
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Yamasaki Hiroshi
Department Of Rehabilitation Medicine St Marianna University School Of Medicine
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Ueno Koichi
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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Ueno Koichi
Departments Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Ch
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Yano Tomohiro
Department Of Food Science Research For Health National Institute Of Health And Nutrition
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Yano Tomohiro
Project For Complementary Factors National Institute Of Health And Nutrition
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Yano Tomohiro
Division Of Applied Food National Institute Of Health And Nutrition
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Fujimoto Eriko
Project For Complementary Factors National Institute Of Health And Nutrition:graduate School Of Phar
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Negishi Etsuko
Dep. Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences Chiba U
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Negishi Etsuko
Graduate School Of Pharmaceutical Sciences Chiba University
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Hagiwara Hiromi
Project For Complementary Factors National Institute Of Health And Nutrition
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Hagiwara Hiromi
Department Of Agricultural Chemistry Shizuoka University
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Ueno Koichi
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Ueno K
Kinki Univ. Nara Jpn
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Ueno Koichi
Dep. Of Geriatric Pharmacology Graduate School Of Pharmaceutical Sciences Chiba Univ.
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Yamasaki Hiroshi
Department Of Parasitology Asahikawa Medical College
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Ueno Koichi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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Yano Tomohiro
Department Of Life Environmental Sciences Faculty Of Life Sciences Toyo University
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Yamasaki Hiroshi
Department Of Hematology And Oncology Kumamoto City Hospital
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Sato Hiromi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University, 6-6-11-1302 Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan
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UENO Koichi
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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Yamasaki Hiroshi
Department of Chemical and Biochemical Engineering, Toyama University
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