Connexin 32 as an Anti-invasive and Anti-metastatic Gene in Renal Cell Carcinoma
スポンサーリンク
概要
- 論文の詳細を見る
Cellular homeostasis in many organs is maintained via gap junctions composed of connexin (Cx), a large protein family with a number of isoforms. In fact, gap junctional intercellular communication (GJIC) is actively involved in all aspects of the cellular life cycle, ranging from cell growth to cell death. It has been well known that Cx gene acts as a tumor suppressor gene due to the maintenance of cellular homeostasis via GJIC. On the other hand, recent data show that GJIC-independent function for Cx gene contributes to tumor-suppressive effect of the gene with cell certain specificity. However, the mechanistic aspect of the GJIC-independent function remains largely unknown. In this review, we briefly summarize the tumor-suppressive effects of Cx genes, refer to a new aspect of Cx32 as an anti-invasive and anti-metastatic gene against renal cell carcinoma in a GJIC-independent function and establishment of a new cancer therapy based on the new function of Cx32.
- 社団法人日本薬学会の論文
- 2006-10-01
著者
-
Ueno K
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
-
Ueno Koichi
Graduate School Of Pharmaceutical Sciences Chiba University
-
Sato Hiromi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
-
YANO Tomohiro
Project for Complementary Factors, National Institute of Health and Nutrition
-
FUJIMOTO Eriko
Project for Complementary Factors, National Institute of Health and Nutrition
-
HAGIWARA Hiromi
Project for Complementary Factors, National Institute of Health and Nutrition
-
SATO Hiromi
Project for Complementary Factors, National Institute of Health and Nutrition
-
YAMASAKI Hiroshi
Faculty of Sciences and Technology, Kwansei Gakuin University
-
NEGISHI Etsuko
Graduate School of Pharmaceutical Sciences, Chiba University
-
Ueno K
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
-
Ueno Koichi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
-
Ueno Koichi
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
-
Ueno Koichi
Departments Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Ch
-
Yano Tomohiro
Project For Complementary Factors National Institute Of Health And Nutrition
-
Yano Tomohiro
Division Of Applied Food National Institute Of Health And Nutrition
-
Fujimoto Eriko
Project For Complementary Factors National Institute Of Health And Nutrition:graduate School Of Phar
-
Negishi Etsuko
Dep. Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences Chiba U
-
Negishi Etsuko
Graduate School Of Pharmaceutical Sciences Chiba University
-
Hagiwara Hiromi
Project For Complementary Factors National Institute Of Health And Nutrition
-
Ueno K
Kinki Univ. Nara Jpn
-
Ueno Koichi
Dep. Of Geriatric Pharmacology Graduate School Of Pharmaceutical Sciences Chiba Univ.
-
Ueno Koichi
Graduate School Of Agriculture Kinki University
-
Ueno Koichi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
-
Yano Tomohiro
Department Of Life Environmental Sciences Faculty Of Life Sciences Toyo University
-
Yamasaki Hiroshi
Faculty of Science, University of the Ryukyus
関連論文
- Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist
- The structure-activity relationship between oxycoumarin derivatives showing inhibitory effects on iNOS in mouse macrophage RAW264.7 cells
- Enhanced Effect of Connexin 43 on Cisplatin-Induced Cytotoxicity in Mesothelioma Cells
- Complexation of Tocotrienol with γ-Cyclodextrin Enhances Intestinal Absorption of Tocotrienol in Rats
- Effect of Acerola Cherry Extract on Cell Proliferation and Activation of Ras Signal Pathway at the Promotion Stage of Lung Tumorigenesis in Mice
- Quercetin Suppresses Bone Resorption by Inhibiting the Differentiation and Activation of Osteoclasts (Pharmacology)
- Establishment and Pathophysiological Characterization of Type 2 Diabetic Mouse Model Produced by Streptozotocin and Nicotinamide(Highlighted paper selected by Editor-in-chief,Pharmacology)
- Comparative study of histamine H4 receptor expression in human dermal fibroblasts
- Expression of Histamine H4 Receptor in Synovial Cells from Rheumatoid Arthritic Patients(Biopharmacy)
- Histamine H4 Receptor Expression in Human Synovial Cells Obtained from Patients Suffering from Rheumatoid Arthritis(Biopharmacy)
- Connexin 32 as an Anti-invasive and Anti-metastatic Gene in Renal Cell Carcinoma
- Cytotoxic Effect of the Her-2/Her-1 Inhibitor PKI-166 on Renal Cancer Cells Expressing the Connexin 32 Gene
- ATTENUATION OF ASPIRIN ANALGESIA BY CALCIUM LOADING IN HEALTHY SUBJECTS
- CHARACTERIZATION AND PURIFICATION OF VARIOUS CARBOXYLESTERASE ISOZYMES FROM RAT LIVER MICROSOME
- NAD-MEDIATED POTENTIATION OF ANTI-CARBOXYLESTERASE ACTION OF EPN (5); PARTICIPATION OF MICROSOMAL DEHYDROGENASE (S)
- IN VIVO INHIBITION OF LIPID PEROXIDE FORMATION BY CLOFIBRATE IN THE RAT
- SPECIES DIFFERENCE IN GLUTATHIONE LEVEL AND GLUTATHIONE RELATED ENZYME ACTIVITIES IN RATS, MICE, GUINEA PIGS AND HAMSTERS
- THE EFFECTS OF ASPIRIN AND ITS METABOLITE, SALICYLIC ACID, ON CULTURED RAT EMBRYO
- INDUCTION OF HEPATIC GLUTATHIONE S-TRANSFERASE ACTIVITIES BY REPEATED ADMINISTRATION OF AMINOPYRINE IN RATS
- PERTURBATION OF HEPATIC GLUTATHIONE LEVEL AND GLUTATHIONE RELATED ENZYME ACTIVITIES BY REPEATED ADMINISTRATION OF AMINOPYRINE IN RATS
- CHANGES OF GAMMA-GLUTAMYLTRANSPEPTIDASE ACTIVITY IN THE RAT DURING DEVELOPMENT AND COMPARISON OF THE FETAL LIVER, PLACENTAL AND ADULT LIVER ENZYMES
- ACETYLSALICYLIC ACID INDUCED FETALTOXICITY AND DRUG METABOLISM
- High Oleic Peanut Oil Modulates Promotion Stage in Lung Tumorigenesis of Mice Treated with Methyl Nitrosourea
- "P-32 In vitro liver injury model induced by P. acnes-LPS in multicellular sphroids composed of rat liver cells formed by rotary culture system.
- CYTOKINE-DEPENDENT IN VITRO RAT LIVER INJURY INDUCED BY P.ACNES AND LPS.
- Inhibition of Expression of Ornithine Decarboxylase by c-myc Antisense Oligonucleotide at the Promotion Stage of Lung Tumorigenesis in Mice
- TEL/AML1 fusion gene resulting from a cryptic t(12;21) is uncommon in adult patients with B-cell lineage ALL and CML lymphoblastic transformation
- A Human T-Cell Lymphotropic Virus Type-I Carrier with Chronic Renal Failure, Aplastic Anemia, Myelopathy, Uveitis, Sjogren's Syndrome and Panniculitis
- GENERAL PHARMACOLOGICAL STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN EXPERIMENTAL ANIMALS
- Induction of Cytochrome P450 1A1 in Mice by Repeated Oral Administration of Propranolol
- Inactivation of Rat Cytochrome P450 2D Enzyme by a Further Metabolite of 4-Hydroxypropranolol, the Major and Active Metabolite of Propranolol
- Fluorescence Detection of DNA Using a Novel Peroxidase Substrate, 4-(4-Hydroxyphenylcarbamoyl)butanoic Acid
- A Novel Method for Determining Peroxidase Activities Using ρ-Acetamidophenol Analogs
- Analysis of Correlation between Prescription Drugs for Climacteric Disorders and CA Repeat Polymorphism of Estrogen Receptor β Gene
- EFFECT OF PRENATAL EXPOSURE OF PARATHION ON HUMORAL IMMUNE FUNCTION IN MICE
- BASAL INVESTIGATION ON THE INTRODUCTION OF DRUG METABOLIZING SYSTEM INTO RAT WHOLE EMBBYO CULTURE SYSTEM
- ON THE DIFFERENT FUNCTION OF CYTOCHROME P-450 ISOZYMES IN LIPID PEROXIDATION
- EFFECTS ON OFFSPRING INDUCED BY ORAL ADMINISTRATION OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE TO THE FEMALE RATS IN PERI-AND POST-NATAL PERIODS
- TERATOLOGICAL STUDY OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN RABBITS
- TERATOLOGICAL STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN RATS
- STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE ON FERTILITY IN RATS
- 2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ethers: Their Cytotoxic Activity
- Neonatal Orbital Teratoma with Intracranial Extension : -Case Report-
- ACTIVE OXYGEN GENERATION BY ALVEOLAR MACROPHAGE IN MICE TREATED WITH CARCINOGEN AND PROMOTER
- A Combined Assay of Cell Vability and in Vitro Cytotoxicity with a Highly Water-Soluble Tetrazolium Salt, Neutral Red and Crystal Violet
- Benzothiazole-Containing Tetrazolium Salts That Produce Water-Soluble Formazan Dyes Absorbing at a Long Wavelength upon NADH Reduction
- 2-(5-Hydrazinocarbonyl-2-oxazolyl)-5,6-dimethoxybenzothiazole as a precolumn fluorescence derivatization reagent for carboxylic acids in high-performance liquid chromatography and its application to the assay of fatty acids in human serum
- 2-(5-Hydrazinocarbonyl-2-furyl)-5, 6-dimethoxybenzothiazole as a Precolumn Fluorescence Derivatization Reagent for Carboxylic Acids in High-Performance Liquid Chromatography and Its Application to the Assay of Fatty Acids in Human Serum
- 329 Productton of Experimental Acute Liver Injury Model Using Multicellular Spheroids Composed of Rat Parenchymal and Non-parenchymal Liver Cells
- Effect of Nonspecific Binding to Microsomes and Metabolic Elimination of Buprenorphine on the Inhibition of Cytochrome P4502D6(Biochemistry/Molecular Biology)
- Nutrients modulating the development of lung adenoma in mice
- 221 A factor contributing to the modulating effect on chemical-induced pulmonary tumorigenesis in mice
- Inhibitory effect of the extracts from Thai medicinal plants on iNOS expression in mouse macrophage RAW 264.7
- Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-α, and COX-2 expression in mouse macrophage RAW 264.7
- Memory and learning-enhancing effect of Daikenchuto, a traditional Japanese herbal medicine, in mice
- Inhibition of the Antibody Production by Acetaminophen Independent of Liver Injury in Mice
- Abatement of Morphine-Induced Slowing in Gastrointestinal Transit by Dai-kenchu-to, a Traditional Japanese Herbal Medicine
- O11-09 Reproductive Immunotoxicity of di-(2-ethyihexyl phthalate(DEHP)in rats
- P-10. Fish micronucleus test using kidney, gill and erythrocytes(Abstracts of the oral and poster presentations)(The 53rd Annual Meeting of the Society of Chromosome Research)
- P-09. Micronucleus test using erythrocytes of Carassius species and Zacco platypus for monitoring genotoxic pollutants in river water(Abstracts of the oral and poster presentations)(The 53rd Annual Meeting of the Society of Chromosome Research)
- Chromosome Aberrations and Survival in Normal and Dechorionated Embryos of Misgurnus anguillicaudatus (Cobitidae, Pisces) Exposed to Mitomycin C
- PRODUCTION OF EXPERIMENTAL ACUTE LIVER INJURY MODEL USING THE MULTICELLULAR SPHEROIDS COMPOSED OF RAT LIVER CELLS.
- FORMATION AND LONG-TERM CULTURE OF SPHEROID COMPOSED OF LONG-EVANS CINNAMON(LEC)RAT LIVER CELLS
- Functional analysis of transcriptional activity of cytosine and adenine (CA) repeats polymorphism in the estrogen receptor β gene
- Vitrigel-sandwich culture system useful for maintaining the functions of rat primary hepatocytes
- Development of a novel culture system for rat primary hepatocytes utilizing extracellular matrix gel membranes and its application(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- Induction of Apoptosis in a Human Breast Cancer Cell Overexpressing ErbB-2 Receptor by α-Tocopheryloxybutyric Acid
- Regulation of Methionine Adenosyltransferase Activity by the Glutathione Level in Rat Liver During Ischemia-Reperfusion
- Evaporation and Combustion of Emulsified Fuel : Onset of Microexplosion
- Complexation of Tocotrienol with γ-Cyclodextrin Enhances Intestinal Absorption of Tocotrienol in Rats
- INFLUENCE OF MATERNAL DRUG METABOLISM ON THE FETAL TOXICITY INDUCED BY ACETYLSALICYLIC ACID
- NAD-Coupled Enzymatic Oxidation of O-Ethyl O-p-Nitrophenyl Phenylphosphonothioate (EPN) to Its Oxygen Analog with Liver Microsomes of Rats
- Experimenta Congenital Hydrocephalus : -Pathogenetic Processes in Differentiating Brain-
- STAGES OF EARLY EMBRYONIC DEVELOPMENT IN WILLOW MINNOW, GNATHOPOGON CAERULESCENS(Developmental Biology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- HYPOCALCEMIC EFFECT OF ACETYLSALICYLIC ACID IN RATS
- A-55. Arteriovenous Malformation of Vertebro-Basilar Tree Special Emphasis on its Classification and Operative Indcation
- ASPIRIN INHIBITION OF HYPERCALCEMIC EFFECT OF 1α-HYDROXYVITAMIN D3 IN RATS
- A novel animal model of pruritus induced by successive application of glucocorticoid to mouse skin
- Antiallergic Activity of Curcuma longa (II) : Features of inhibitory actions on histamine release from mast cells
- Antiallergic Activity of Curcuma longa (I) : Effectiveness of Extracts Containing Curcuminoids
- Development of a Multi-Scale Electromigration Simulator Based on a Combination of Ultra Accelerated Quantum Chemical Molecular Dynamics and Kinetic Monte Carlo Methods Application to Cu Interconnects Lifetime Simulation
- Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten
- The Histamine H_2-Receptor Antagonist, Cimetidine, Inhibits the Articular Osteopenia in Rats With Adjuvant-Induced Arthritis by Suppressing the Osteoclast Differentiation Induced by Histamine
- The Inhibitory Effect of Vitamin E on Arachidonic Acid Metabolism during the Process of Urethane-Induced Lung Tumorigenesis in Mice
- Antiallergic Activity of Curcuma longa (II) : Features of inhibitory actions on histamine release from mast cells
- A New Brackish-water Species of Echinoderes (Kinorhyncha: Cyclorhagida) from the Seto Inland Sea, Japan
- New 2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ether Compound Induces Microtubule Depolymerization and Subsequent Apoptosis
- Multi-angle observation scheme for bubbles and droplets
- Sex-related differences in pharmacokinetics and pharmacodynamics of anti-hypertensive drugs
- Effects of heptaminol AMP amidate on suppressor and helper function of murine T cells.
- Effects of heptaminol AMP amidate(HAA) on cyclic AMP level and mitogen-induced proliferation of murine spleen cells.
- ML-5 GENOMIC INSTABILITY AND ENVIRONMENTAL CARCINOGENESIS
- Enhancement of the binding of O-ethyl O-p-nitrophenyl phenylphosphonate (EPNoxon) to microsomal carboxylesterase by NAD in vitro.
- Effect of heptaminol AMP amidate, a new nucleotide derivative, on in vitro humoral immunity.
- The Prevention of Oxy Radical-Mediated Lung Tumorigenesis in Mice by Vitamin E
- Nototanaids (Crustacea: Tanaidacea) from Japan, with the Description of a New Species of Nototanoides