Induction of Apoptosis in a Human Breast Cancer Cell Overexpressing ErbB-2 Receptor by α-Tocopheryloxybutyric Acid

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概要

• 論文の詳細を見る

• The overexpression of ErbB-2 receptor relates to malignant transformation of breast cancer. The present study was carried out to establish the usefulness of α-tocopheryloxybutyric acid (TE) as a chemotherapeutic agent for human breast cancer. TE caused induction of apoptosis in MDA-MB-453 cells overexpressing the ErbB-2 receptor. TE reduced levels of activated ErbB-2 receptor and Akt. In contrast, TE induced the activation of p38, and SB203580, a specific inhibitor for p38, attenuated the TE-induced apoptosis. These data indicate that simultaneous occurrences of Akt inhibition and p38 activation by TE result in the cell death.

• 社団法人 日本薬理学会の論文
• 2002-08-01

著者

• SUZUKI Kazuyuki

  Department of Internal Medicine, School of Medicine Iwate Medical University

• YANO Tomohiro

  Department of Nephrology and Rheumatology, Kinki University Faculty of Medicine

• SATOH Haruna

  Department of Food Science Research for Health, National Institute of Health and Nutrition

• HAGIWARA Kiyokazu

  Department of Food Science Research for Health, National Institute of Health and Nutrition

• Hagiwara Kiyokazu

  Department Of Food Science Research For Health National Institute Of Health And Nutrition

• Asano Ryuji

  Department Of Veterinary Medicine College Of Bioresource Sciences Nihon University

• Asano Ryuji

  Department Of Veterinary Pharmacology College Of Bioresource Sciences Nihon University

• Satoh Haruna

  Department Of Food Science Research For Health National Institute Of Health And Nutrition

• Yano Tomohiro

  Department Of Food Science Research For Health National Institute Of Health And Nutrition

• Yano Tomohiro

  Division Of Applied Food National Institute Of Health And Nutrition

• NISHIKAWA KAZUHIRO

  Department of Surgery, Osaka General Medical Center

• AKAZAWA Akihiko

  Department of Veterinary Pharmacology, College of Bioresource Sciences, Nihon University

• KUMADAKI Itsumaru

  Faculty of Pharmaceutical Sciences, Setsunan University

• JAE SHIN

  Department of Food Science Research for Health, National Institute of Health and Nutrition

• Akazawa Akihiko

  Department Of Veterinary Pharmacology College Of Bioresource Sciences Nihon University

• Nishikawa Kazuhiro

  Department Of Electronic Engineering And Computer Science Osaka Electro-communication University

• Nishikawa Kazuhiro

  Department Of Veterinary Pharmacology College Of Bioresource Sciences Nihon University

• Suzuki Kazuyuki

  Department Of Gastroenterology And Hepatology Iwate Medical University School Of Medicine

• Jae Shin

  Department Of Food Science Research For Health National Institute Of Health And Nutrition

• Kumadaki Itsumaru

  Faculty Of Pharmaceutical Sciences Setsunan University

• Suzuki Kazuyuki

  Department Of Applied Chemistry Graduate School Of Engineering Nagoya University

• Suzuki Kazuyuki

  Department Of Veterinary Pharmacology College Of Bioresource Sciences Nihon University

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