The Inhibitory Effect of Vitamin E on Arachidonic Acid Metabolism during the Process of Urethane-Induced Lung Tumorigenesis in Mice

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概要

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• It is known that change in the arachidonic acid metabolism plays an important role in the development of tumors. This study was undertaken to understand the relationship of changes in lipoxygenase, cyclooxygenase and ornithine decarboxylase (ODC) to the inhibitory effect of vitamin E on urethane-induced lung tumorigenesis in mice. We analyzed the inhibitory effect of vitamin E on ornithine decarboxylase, cyclooxygenase and lipoxygenase activities at a promotion phase of lung tumorigenesis in mice. An increase in the ODC of urethane treated-mice and no significant change in the ODC of VE-treated mice were observed. An increase in the production of PGE2 and all HETES tested in the lungs of the urethane-treated mice was observed at week 8 after injection (promotion phase), showing a significant difference compared to the control group. Excessive vitamin E feeding during the initiation or promotion phases inhibited the increase in PGE2 and HETES produced by urethane treatment. These results suggest that the suppression of prostagrandin metabolism and ODC may be associated with the in-hibitory effect of vitamin E against urethane-induced lung tumorigenesis.

• 財団法人 学会誌刊行センターの論文

著者

• YANO Yoshihisa

  Department of Biochemistry, Osaka City University Medical School

• Yano Yoshihisa

  Department Of Biochemistry Osaka City University Graduate School Of Medicine

• Yano Tomohiro

  Division Of Applied Food National Institute Of Health And Nutrition

• ICHIKAWA Tomio

  School of Life Environmental Sciences, Mukogawa Womens University

• UCHIDA Mikako

  School of Life Environmental Sciences, Mukogawa Womens University

• MURAKAMI Ayumi

  School of Life Environmental Sciences, Mukogawa Womens University

• OTANI Shuzou

  Department of Biochemistry, Osaka City University Medical School

• ICHIKAWA Tomio

  School of Life Environmental Sciences, Mukogawa Women's University

• UCHIDA Mikako

  School of Life Environmental Sciences, Mukogawa Women's University

• YANO Tomohiro

  Division of Applied Food Research, The National Institute of Health

• MURAKAMI Ayumi

  School of Life Environmental Sciences, Mukogawa Women's University

• YANO Yoshihisa

  Department of Advanced Energy, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan

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