STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE ON FERTILITY IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
A fertility study was carried out in Slc : SD rats orally administered Hydroxypropylmethylcellulose acetate succinate (HPMCAS), a useful pharmaceutical excipient, at dose levels of 625, 1,250 and 2,500 mg/kg/day. Male rats were treated with HPMCAS from 60 days before pairing until the completion of mating. Female rats received HPMCAS for 22 days, from 14 days prior to mating up to Day 7 of gestation. All pregnant females were sacrificed on Day 21 of gestation and all fetuses were examined for abnormalities. No abnormal signs were seen in mating or fertility in the rat treated with HPMCAS. No external, internal and skeletal anomalies attributable to HPMCAS were observed in the fetuses. It was concluded that HPMCAS had no harmful effect on mating, fertilization, implantation, or embryonic development.
- 日本トキシコロジー学会の論文
- 1985-10-31
著者
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Ueno Koichi
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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Igarashi Takashi
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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KITAGAWA HARUO
Laboratory of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba
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Ueno K
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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Ueno Koichi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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Igarashi Takashi
Department Of Pediatrics Branch Hospital Faculty Of Medicine University Of Tokyo
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Ueno Koichi
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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HOSHI Noboru
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluatign and Toxicolo
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Hoshi Noboru
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluatign And Toxicolog
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Kondo Yuko
Nippon Bio-test Laboratories Inc.
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Kitagawa Haruo
Laboratory Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Chiba University:division Of Anal
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Kitagawa Haruo
Laboratory Of Biochemical Pharmacology And Blotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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Kitagawa Haruo
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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Igarashi T
Eisai Co. Ltd. Ibaraki Jpn
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FUJITA Teruko
Nippon Bio-Test Laboratories Inc.
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ICHIKAWA Nobuo
Nippon Bio-Test Laboratories Inc.
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ISODA Masae
Department of Pathology, Nippon Veterinary and Zootechnical College
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Isoda Masae
Department Of Pathology Nippon Veterinary And Zootechnical College
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ICHIKAWA Naoto
Bio-Medical Research Laboratories Co., Ltd.
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Ichikawa Naoto
Bio-medical Research Laboratories Co. Ltd.
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Kitagawa Haruo
Laboratory Of Biochemical Pharmacology And Toxicology Faculty Of Pharmaceutical Sciences Chiba Unive
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Kitagawa Haruo
Analytical And Metabolic Research Laboratories And Biological Research Laboratories Sankyo Co. Ltd.:
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Ueno Koichi
Dep. Of Geriatric Pharmacology Graduate School Of Pharmaceutical Sciences Chiba Univ.
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Kitagawa H
Laboratory Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Chiba University:division Of Anal
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Igarashi Takashi
千葉大学 薬
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Igarashi Takashi
Analytical And Metabolic Research Laboratories And Biological Research Laboratories Sankyo Co. Ltd.:faculty Of Pharmaceutical Sciences Chiba University
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KITAGAWA Haruo
Laboratory of Biochemical Pharmacology and Biotoxicology
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UENO Koichi
Laboratory of Biochemical Pharmacology and Biotoxicology
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