Expression of Histamine H4 Receptor in Synovial Cells from Rheumatoid Arthritic Patients(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
The last of four histamine receptors (HRs), H4 receptor (H4R), was identified in the year 2000. Since that time, the H4R has been implicated in cellular mechanisms related to immune systems, inflammatory processes, and allergic reactions. We have previously reported the expression of H4R mRNA in rheumatoid arthritic (RA) synovial cell cultures by means of the RT-PCR method. The present study demonstrates the expression of H4R at the protein level in RA synovial cell cultures. We also identified that the receptor was expressed in two specific types of cell populations, fibroblast-like and macrophage-like cells from RA synovial tissues. In the culture system, the fifth generation of fibroblast-like synoviocytes showed as strong expression of H4R as in the primary culture. The results provide pragmatic evidence for H4R as a novel target in the development of pharmacotherapeutic agents for RA treatment. Furthermore, the culture system used here will be useful for future studies concerning basic molecular mechanisms underlying the pharmacology of H4R.
- 社団法人日本薬学会の論文
- 2007-11-01
著者
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UENO Koichi
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, C
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Suzuki Masahiko
Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University
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Ikawa Yoshiko
Department Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences C
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Ikawa Yoshiko
千葉大学 薬学研究院高齢者薬剤学
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Ikawa Yoshiko
千葉大学 大学院薬学研究院高齢者薬剤学研究室
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Ikawa Yoshiko
千葉大学 大学院薬学研究院高齢者薬物学
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Ueno Koichi
Dep. Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chiba Uni
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Ohki Emi
Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences,Chib
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AOE Tomohiko
Department of Anesthesiology, Graduate School of Medicine, Chiba University
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NEGISHI Etsuko
Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chi
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Ohki Emi
Department Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences C
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Ueno Koichi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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Ueno Koichi
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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Aoe Tomohiko
Department Of Anesthesiology Graduate School Of Medicine Chiba University
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Negishi Etsuko
Dep. Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences Chiba U
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Negishi Etsuko
Graduate School Of Pharmaceutical Sciences Chiba University
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Ueno Koichi
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Ikawa Yoshiko
Department Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences C
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Suzuki Masahiko
Department Of Orthopedic Surgery Graduate School Of Medicine Chiba University
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Suzuki Masahiko
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Ueno Koichi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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UENO Koichi
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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