Formulation Study of Intravesical Oxybutynin Instillation Solution with Enhanced Retention in Bladder
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概要
- 論文の詳細を見る
A formulation study of intravesical oxybutynin (OB) preparations was carried out in order to improve the effectiveness in intravesical instillation therapy for spastic neurogenetic bladder. Sodium hyaluronate (HYA) was introduced to enhance the muco-adhesiveness of the instillation preparation, and the physicochemical properties of the OB formulation were evaluated in comparison with a conventional formulation containing hydroxypropyl-cellulose (HPC). The viscous properties and in vitro adhesiveness increased with the amount of the polymeric additives, and retention properties of OB in rabbit bladder were comparable after addition of 0.4% HYA and 1.0% HPC. HYA was able to enhance the intravesical retention properties of OB instillation solution to a lesser degree than HPC, it seemed to be a useful additive in the OB instillation due to its safety and mucosal-protective effect.
- 公益社団法人日本薬学会の論文
- 2008-08-01
著者
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Suzuki Masahiko
Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University
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Hanawa Takehisa
Department of Pharmacy, Yamanashi Medical University
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Oguchi Toshio
Department Of Pharmacy University Hospital University Of Yamanashi
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ENDO Naoko
Department of Biochemistry University of Shizuoka, School of Pharmaceutical Sciences
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Endo Naoko
Department Of Pharmacy University Hospital University Of Yamanashi
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Suzuki Taeko
Department Of Clinical Pharmaceutics Meiji Pharmaceutical University
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Hanawa T
Graduate School Of Pharmaceutical Sciences Chiba University
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HANAWA KAZUMI
Department of Pharmacy, Yamanashi Medical University
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Mohri Kiminori
Department Of Clinical Pharmaceutics Meiji Pharmaceutical University
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TSUCHIYA Chikako
Department of Pharmacy, University Hospital, University of Yamanashi
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Suzuki Masahiko
Department Of Pharmacy University Hospital University Of Yamanashi
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Suzuki Masahiko
Department Of Orthopedic Surgery Graduate School Of Medicine Chiba University
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Suzuki Masahiko
Department Of Orthopaedic Surgery Chiba University Graduate School Of Medicine
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Suzuki Masahiko
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Hanawa Takehisa
Department of Pharmacy, University Hospital, University of Yamanashi
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HANAWA Kazumi
Department of Pharmacy, University Hospital, University of Yamanashi
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