Evaluation of the Efficacy of Pramipexole for Treating Levodopa-induced Dyskinesia in Patients with Parkinson's Disease
スポンサーリンク
概要
- 論文の詳細を見る
Objective The long-term use of levodopa to treat Parkinson's disease (PD) is often limited by the development of motor complications (e.g. levodopa-induced dyskinesia, LID). We hypothesized that a non-ergot dopamine agonist with strong affinity for D3 dopamine receptors (pramipexole) may improve LID in patients taking an ergot D1/D2 dopamine agonist. Methods Patients with PD and LID being treated with levodopa in addition to an ergot dopamine agonist were randomized to either a group in which pramipexole was added to current medications or a group in which the ergot dopamine agonist was switched to pramipexole. Dyskinesia was evaluated using Core Assessment Program for Surgical Interventional Therapies scores. The Unified Parkinson's Disease Rating Scale scores, Modified Hoehn and Yahr stages (at 'on' time), Parkinson's Disease Questionnaire-39 scores and Clinical Global Impression-Improvement scores were also used for evaluation. Results At 24 weeks, pramipexole alleviated LID with more efficiency in the switch group. Conclusion Pramipexole may be a therapeutic option for treating LID because its effects on D3 dopamine receptors may balance the D1 dopamine receptor supersensitivity associated with LID.
著者
-
Kano Osamu
Department of Neurology, Toho University Omori Medical Center
-
Okuma Yasuyuki
Department Of Neurology Juntendo University Shizuoka Hospital
-
Kubo Shin-ichiro
Department Of Neurology Juntendo University School Of Medicine
-
Hashida Hideji
Department Of Neurology Graduate School Of Medicine The University Of Tokyo
-
Tomimitsu Hiroyuki
Department Of Neurology And Neurological Science Graduate School Of Medical And Dental Sciences Toky
-
Hattori Nobutaka
Department Of Neurology Juntendo University School Of Medicine
-
Suzuki Yutaka
Division Of Neurology Department Of Medicine Nihon University School Of Medicine
-
Suzuki Masahiko
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
-
Murakami Hidetomo
Department Of Neurology Showa University Fujigaoka Hospital
-
Utsumi Hiroya
Department of Neurology, Tokyo Medical University, Japan
-
Nanri Kazunori
Department of Neurology, Tokyo Medical University Hachioji Medical Center
-
Iijima Mutsumi
Department of Neurology, Tokyo Women's Medical University, Japan
-
Matsumura Miyuki
Department of Neurology, Institute of Geriatrics, Tokyo Women's Medical University, Japan
-
Iijima Mutsumi
Department of Neurology, Tokyo Women's Medical University, Japan
-
Iijima Mutsumi
Department of Neurology, Tokyo Women's Medical University
-
Matsumura Miyuki
Department of Neurology, Institute of Geriatrics, Tokyo Women's Medical University, Japan
-
Kano Osamu
Department of Neurology, The Methodist Neurological Institute, Weill Cornell Medical College
-
Tomimitsu Hiroyuki
Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Japan
関連論文
- Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist
- Peripheral Arterial Atherosclerosis in Patients with Extracranial, not Intracranial, Arterial Stenosis
- Mutational Analysis of Fukutin Gene in Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy(Molecular Cardiology)
- A Distinct Phenotype of Leg Hyperreflexia in a Japanese Family with Gerstmann-Sträussler-Scheinker Syndrome (P102L)
- Adenosine A_1 receptors using 8-dicyclopropylmethyl-1-[^C]methyl-3-propylxanthine PET in Alzheimer's disease
- Linear Medullary Pericanal Lesion with Longitudinal Myelitis can be Diagnostic of Neuromyelitis Optica
- OJ-117 Predictors of Deep Venous Thrombosis and Pulmonary Arterial Thromboembolism after Total Knee Replacement Using Multislice CT in Logistic Regression Models(Thromboembolism/Antithrombotic therapy/Thrombolysis-2 (H) OJ20,Oral Presentation (Japanese),T
- Transient Restricted Diffusion of Whole Corpus Callosum and Symmetrical White Matter in Epilepsy
- Incidence of Asymptomatic Pulmonary Arterial Thrombi Following Deep Vein Thrombi in Total Knee Arthroplasty : Comparative Evaluation of Three Techniques (Thrombosis/Thrombolysis 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Socie
- Comparative study of histamine H4 receptor expression in human dermal fibroblasts
- Expression of Histamine H4 Receptor in Synovial Cells from Rheumatoid Arthritic Patients(Biopharmacy)
- Histamine H4 Receptor Expression in Human Synovial Cells Obtained from Patients Suffering from Rheumatoid Arthritis(Biopharmacy)
- LRRK2 P755L variant in sporadic Parkinson's disease
- The genomic structure and expression of MJD, the Machado-Joseph disease gene
- Germline mutations of the APC gene in Korean familial adenomatous polyposis patients
- Takotsubo (Ampulla-shaped) Cardiomyopathy Associated with Microscopic Polyangiitis
- Physical map and haplotype analysis of 16q-linked autosomal dominant cerebellar ataxia (ADCA) type III in Japan
- Human skeletal muscle calcium channel α1S is expressed in the basal ganglia: distinctive expression pattern among L-type Ca^ channels
- Autosomal recessive juvenile parkinsonism : A key to understanding nigral degeneration in sporadic Parkinson's disease
- AGE-ASSOCIATED CHANGE IN HEPATIC MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITIES
- Rationale and Design of the Carotid Plaque in Human for All Evaluations With Aggressive Rosuvastatin Therapy (CHALLENGER Trial) : Evaluation by Magnetic Resonance Imaging(Imaging)
- Familial Amyotrophic Lateral Sclerosis with a Novel G85S Mutation of Superoxide Dismutase 1 Gene: Clinical Features of Lower Motor Neuron Disease
- Repeated Non-enhancing Tumefactive Lesions in a Patient with a Neuromyelitis Optica Spectrum Disorder
- Classification of Cerebellar Atrophy Using Voxel-based Morphometry and SPECT with an Easy Z-score Imaging System
- UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase in nuclei and rimmed vacuoles of muscle fibers in DMRV (distal myopathy with rimmed vacuoles)
- Repeat Hepatectomy for Recurrent Colorectal Metastases
- Small cell neuroendocrine carcinoma of the ampulla of Vater with foci of squamous differentiation : a case report
- Longer than 3-Year Survival Following Hepato-Ligamento-Pancreatoduodenectomy for Hilar Cholangiocarcinoma with Vascular Involvement : Report of a Case
- Preparatory hepatic resection with right hepatic vein reconstruction for paracaval liver tumor
- Cholangitis score : a scoring system to predict severe cholangitis in gallstone pancreatitis
- Development of Sarpogrelate External Preparation for Intractable Pain Control. I. Pre-formulation Study on Application of Modified β-Cyclodextrins
- Current Perception Threshold and Sympathetic Skin Response in Diabetic and Alcoholic Polyneuropathies
- EFFECTS OF ANGIOTENSIN II ON THE MEDULLARY NEURONS AND THEIR SENSITIVITY TO ACETYLCHOLINE AND CATECHOLAMINES
- Leaching Mechanisms of Di-(2-Ethylhexyl) Phthalate from Polyvinyl-Chloride Tube during the Administration of Enteral Nutrition
- Dissolution of DEHP from PVC Administration Tube : Estimation of DEHP Dissolution Based on HCO 60 Concentration and Drip Conditions
- Development of Patient-Friendly Preparations : Preparation and Characterization of Allopurinol Gelatin Gel Containing Polyethylene(oxide)
- Treatment Strategies for Perianal Rhabdomyosarcoma : Report of Two Cases
- Blurred Vision With Acute Hypertension Indicating Hypertensive Brainstem Encephalopathy : Case Report
- Influenza-associated Monophasic Neuromyelitis Optica
- Diabetic Nephropathy in KK and KK-A^y Mice
- Pramipexole Reduces the Prevalence of Fatigue in Patients with Parkinsons Disease
- Evaluation of joint laxity against distal traction force upon flexion in cruciate-retaining and posterior-stabilized total knee arthroplasty
- A case of spontaneous hemoarthrosis after a total knee arthroplasty
- Possible Neuro-Sweet Disease Mimicking Brain Tumor in the Medulla Oblongata : Case Report
- Autosomal recessive early -onset parkinsonism with diurnal fluctuation : clinicopathologic characteristics and molecular genetic identification
- Formulation Study of Intravesical Oxybutynin Instillation Solution with Enhanced Retention in Bladder
- Direct and Selective Syntheses of α, α-Dichloroethyl Ketones or Their Ethyl Trimethylsilyl Mixed Acetals by the Reactions of Methoxymethyl or Etyhyl Carboxylates with 1, 1-Dichloroethyllithium in the Presence of Chlorotrimethylsilane
- METHYLENETETRAHYDROFOLATE REDUCTASE AND REDUCED FOLATE CARRIER-1 GENOTYPES AND METHOTREXATE SERUM CONCENTRATIONS IN PATIENTS WITH RHEUMATOID ARTHRITIS
- Posterior Reversible Encephalopathy Syndrome Complicating Intracranial Hemorrhage After Phenylpropanolamine Exposure : Case Report
- Case of probable Creutzfeldt-Jakob disease presenting with complex partial seizure following sleeplessness and cognitive impairment
- 流体力学を応用した光ヘッドｰディスク間隔の安定狭細化
- Genotype-phenotype correlation : Familial Parkinson disease
- On the Topological Types of Singularities of Brieskorn-Pham Type
- Biphasic Hypothermia in Mice Infected with a Parasitic Nematode, Trichinella spiralis
- Programmable Shunt Valves : In Vitro Assessment of Safety of the Magnetic Field Generated by a Portable Game Machine
- Autosomal recessive juvenile Parkinson's disease with partial Trisomy of chromosome 6q syndrome : A case report
- Results of revision total hip arthroplasty with Anatomic BR stem : 10-year minimum follow-up
- Animal models of Parkinson's disease : Similarities and differences between the disease and models
- _L-Leucine Transport in Isolated Protoplasts of Vinca Suspension Culture : Characterization of Uptake
- PLA2G6 variant in Parkinson's disease
- Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease
- Sudden Deafness and Facial Diplegia in Guillain-Barré Syndrome: Radiological Depiction of Facial and Acoustic Nerve Lesions
- Validity and Reliability Assessment of a Japanese Version of the Snaith-Hamilton Pleasure Scale
- Formulation Study on Retinoic Acid Gel Composed of Iota-Carrageenan, Polyethylene Oxide and Emulgen® 408
- Rectal Ulcer in a Patient with VZV Sacral Meningoradiculitis (Elsberg Syndrome)
- A Case of Posterior Spinal Artery Syndrome in the Cervical Cord: A Review of the Clinicoradiological Literature
- Reversible Cerebral Vasoconstriction Syndrome Presenting as Cortical Subarachnoid Hemorrhage
- Isolated Proximal Leg Paresis due to a Small Cortical Infarction
- Subacute Longitudinal Myelitis Associated with Behcet's Disease
- Isolated Reversible Splenial Lesion in Adult Meningitis: A Case Report and Review of the Literature
- Clinical Study of the Responsible Lesion for Dysarthria in the Cerebellum
- Current Perception Threshold and Sympathetic Skin Response in Diabetic and Alcoholic Polyneuropathies
- Smell Identification in Japanese Parkinson's Disease Patients: Using the Odor Stick identification Test for Japanese Subjects
- Measurement of Thrombus Flux Using Transesophageal Echocardiography
- Reversible Focal Cerebral Cortical Lesions in a Patient with Heat Stroke
- Eosinophilic Meningitis Caused by Primary Angiitis of the Central Nervous System
- Evaluation of the Efficacy of Pramipexole for Treating Levodopa-induced Dyskinesia in Patients with Parkinson's Disease
- Crowned Dens Syndrome Mimicking Meningitis
- Ophthalmoplegia and Flaccid Paraplegia in a Patient with Anti-NMDA Receptor Encephalitis: A Case Report and Literature Review
- Validity of Single Tract Microelectrode Recording in Subthalamic Nucleus Stimulation
- Intravenous Immunoglobulin Therapy for Autoantibody-Positive Cerebellar Ataxia
- Retroperitoneal Fibrosis Secondary to Pergolide Therapy
- Restricted rotation involving the tetrahedral carbon. XXXIX. 9-(2-Methoxy-1-methylethyl)triptycene derivatives.
- Restricted rotation involving the tetrahedral carbon. LII. Rotational barriers in 1,2,3,4-tetrafluoro- and 1,4-dimethoxy-9-(1-cyano-1-methylethyl)triptycenes.
- 11C-PiB PET Imaging of Encephalopathy Associated with Cerebral Amyloid Angiopathy