11C-PiB PET Imaging of Encephalopathy Associated with Cerebral Amyloid Angiopathy
スポンサーリンク
概要
- 論文の詳細を見る
We herein report that the clinical, laboratory, and radiographic features and positron emission tomography (PET) imaging may provide valuable clues to the pathogenesis of cerebral amyloid angiopathy (CAA)-associated encephalopathy, which currently remains unclear. We herein describe two cases of encephalopathy with CAA, with an emphasis on PET imaging with 11C-Pittsburgh compound B (11C-PiB) and 18F-fluorodeoxyglucose (18F-FDG). One case of Alzheimer's disease for which a brain biopsy was performed showed CAA-related inflammation. Another case that had developed sudden sensory aphasia presented with posterior reversible encephalopathy syndrome-like vasogenic edema in the left temporal region with 11C-PiB uptake and microhemorrhages. 11C-PiB and 18F-FDG PET are useful for detecting CAA-associated encephalopathy, including atypical CAA cases.
- 一般社団法人 日本内科学会の論文
著者
-
Ishiwata Kiichi
Positron Medical Center Tokyo Metropolitan Institute Of Gerontology
-
Ishii Kenji
Positron Medical Center Tokyo Metropolitan Institute Of Gerontology
-
Hashimoto Masaya
Department Of Internal Medicine Takao Hospital
-
Fukuda Takahiro
Department Of Mechanical Systems Engineering Faculty Of Engineering Kogakuin University
-
Tokumaru Aya
Department Of Diagnostic Radiology Tokyo Metropolitan Medical Center Of Gerontology
-
Matsushima Satoshi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Okayama University
-
Suzuki Masahiko
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
-
Sengoku Renpei
Department of Neurology, The Jikei University School of Medicine, Japan
-
Ishiwata Kiichi
Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
-
Murakami Yoshitake
Department of Neurology, Saiseikai Kurihashi Hospital, Japan
-
Mochio Soichiro
The Jikei University School of Nursing, Japan
関連論文
- Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist
- Preclinical and the first clinical studies on [^C]CHIBA-1001 for mapping α7 nicotinic receptors by positron emission tomography
- Low density of sigma_1 receptors in early Alzheimer's disease
- Correlation between each task of the Mini-Mental State Examination and regional glucose hypometabolism in at-rest Alzheimer's disease patients
- Benzodiazepine Receptor Distribution and Cerebral Blood Flow in Early Blindness : A PET Study
- Semi-Automatic ROI Placement System for Analysis of Brain PET Images Based on Elastic Model : Application to Diagnosis of Alzheimer's Disease
- Preserved benzodiazepine receptors in Alzheimer's disease measured with C-11 flumazenil PET and I-123 iomazenil SPECT in comparison with CBF
- Yozinkodakuto, a traditional Chinese (Japanese Kampo) medicine, improves the creatinine level in chronic renal failure
- Adenosine A_1 receptors using 8-dicyclopropylmethyl-1-[^C]methyl-3-propylxanthine PET in Alzheimer's disease
- Successive positron emission tomography measurement of cerebral blood flow and neuroreceptors in the human brain : an ^C-SA4503 study
- Influence of mild hyperglycemia on cerebral FDG distribution patterns calculated by statistical parametric mapping
- Low density of sigma_1 receptors in early Alzheimer's disease
- Shortened protocol in practical [^C]SA4503-PET studies for sigma_1 receptor quantification
- Distribution volume as an alternative to the binding potential for sigma_1 receptor imaging
- Evaluation of tumor growth in vivo in a rat model of liver metastasis, using a newly devised index obtained by positron emission tomography with [18F] FDG
- A feasibility study of [^C]SA4503-PET for evaluating sigma_1 receptor occupancy by neuroleptics : the binding of haloperidol to sigma_1 and dopamine D_2-like receptors
- Tumor viability evaluation by positron emission tomography with [^F]FDG in the liver metastasis rat model
- Regional Differences in Blood Volume and Blood Transit Time in Resting Skeletal Muscle
- Imaging of adenosine A_1 receptors in the human brain by positron emission tomography with [^C]MPDX
- Potential of an adenosine A_ receptor antagonist [^C]TMSX for myocardial imaging by positron emission tomography : a first human study
- Adenosine A_ receptor imaging with [^C]KF18446 PET in the rat brain after quinolinic acid lesion : Comparison with the dopamine receptor imaging
- Preclinical studies on [^C]MPDX for mapping adenosine A_1 receptors by positron emission tomography
- Intrasubject correlation between static scan and distribution volume images for [^C]flumazenil PET
- Preserved benzodiazepine receptors in Alzheimer's disease measured with C-11 flumazenil PET and I-123 iomazenil SPECT in comparison with CBF
- Comparison of three PET dopamine D_2-like receptor ligands, [^C]raclopride, [^C]nemonapride and [^C]N-methylspiperone, in rats
- Semi-Automatic ROI Placement System for Analysis of Brain PET Images Based on Elastic Model : Application to Diagnosis of Alzheimer's Disease
- Metabolite analysis of [^C]flumazenil in human plasma : Assessment as the standardized value for quantitative PET studies
- Usefulness of [^C]Methionine PET in the Diagnosis of Dysembryoplastic Neuroepithelial Tumor with Temporal Lobe Epilepsy
- Preclinical evaluation of [^C]SA4503: radiation dosimetry, in vivo selectivity and PET imaging of sigma_1 receptors in the cat brain
- Long-term performance evaluation of positron emission tomography : analysis and proposal of a maintenance protocol for long-term utilization
- Radiosynthesis and Biodistribution in Mice of a ^F-Labeled Analog of O-1302 for Use in Cerebral CB1 Cannabinoid Receptor Imaging(Medicinal Chemistry)
- Methoxy- and Fluorine-Substituted Analogs of O-1302 : Synthesis and in Vitro Binding Affinity for the CB1 Cannabinoid Receptor
- Radiosynthesis and Evaluation of ^C-Labeled Diaryl-Substituted Imidazole and Indole Derivatives for Mapping Cyclooxygenase-2(Biopharmacy)
- OJ-117 Predictors of Deep Venous Thrombosis and Pulmonary Arterial Thromboembolism after Total Knee Replacement Using Multislice CT in Logistic Regression Models(Thromboembolism/Antithrombotic therapy/Thrombolysis-2 (H) OJ20,Oral Presentation (Japanese),T
- Incidence of Asymptomatic Pulmonary Arterial Thrombi Following Deep Vein Thrombi in Total Knee Arthroplasty : Comparative Evaluation of Three Techniques (Thrombosis/Thrombolysis 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Socie
- Rasmussen Syndrome : Multifocal Spread of Inflammation Suggested from MRI and PET Findings
- Comparative study of histamine H4 receptor expression in human dermal fibroblasts
- Expression of Histamine H4 Receptor in Synovial Cells from Rheumatoid Arthritic Patients(Biopharmacy)
- Histamine H4 Receptor Expression in Human Synovial Cells Obtained from Patients Suffering from Rheumatoid Arthritis(Biopharmacy)
- Functional and Neuroreceptor Imaging of the Brain in Bicuculline-Induced Dystonic Rats
- Mechanism of Protection by S-(1, 2-Dicarboxyethyl)glutathione Triester against Acetaminophen-Induced Hepatotoxicity in Rat Hepatocytes
- Relationship Between Stroke and Asymptomatic Minute Hemorrhages in Hypertensive Patients
- Voxel- and ROI-based statistical analyses of PET parameters for guidance in the surgical treatment of intractable mesial temporal lobe epilepsy
- A Case of Multiple Sclerosis with Homonymous Hemianopia Examined by Positron Emission Tomography
- MNS-09 INSECT-INSPIRED WALL-CLIMBING ROBOTS UTILIZING SURFACE TENSION FORCES(Micro/Nanosystem Science and Technology III,Technical Program of Oral Presentations)
- II E2 Voxel based and ROI based statistical analysis of PET paramenters as guides for surgical treatment of intractable mesial temporal lobe epilepsy
- II D6 Usefulness of C11-methionine PET in the diagnosis of benign tumors presenting with temporal lobe epilepsy
- Synthesis and evaluation of vesamicol analog (-)-o-[^C]methylvesamicol as a PET ligand for vesicular acetylcholine transporter
- AGE-ASSOCIATED CHANGE IN HEPATIC MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITIES
- Glucose Metabolism in the Visual Structures of Rat Monocularly Deprived by Eyelid Suture after Postnatal Eye Opening
- Adenosine A_1 and Benzodiazepine Receptors and Glucose Metabolism in the Visual Structures of Rats Monocularly Deprived by Enucleation or Eyelid Suture at a Sensitive Period
- Neuroimaging Analysis of a Case with Left Homonymous Hemianopia and Left Hemispatial Neglect
- Neuroreceptor Bindings and Synaptic Activity in Visual System of Monocularly Enucleated Rat
- Evaluation of iodinated and brominated [^C]styrylxanthine derivatives as in vivo radioligands mapping adenosine A_2A receptor in the central nervous system
- A brain uptake study of [1-^C]hexanoate in the mouse: The effect of hypoxia, starvation and substrate competition
- Synthesis and preliminary evaluation of [1-^C]hexanoate as a PET tracer of fatty acid metabolism
- Improvement of likelihood estimation in Logan graphical analysis using maximum a posteriori for neuroreceptor PET imaging
- Search for PET probes for imaging the globus pallidus studied with rat brain ex vivo autoradiography
- Further characterization of a CNS adenosine A_ receptor ligand [^C]KF18446 with in vitro autoradiography and in vivo tissue uptake
- A stereotoxic method of anatomical localization by means of H_2^O positron emission tomography applicable to the brain activation study in cats: Registration of images of cerebral blood flow to brain atlas
- Myocardial adenosine A_ receptor imaging of rabbit by PET with [^C]KF17837
- Effects of reserpine treatment on the dopamine receptor binding of [^3H/^C]nemonapride in the mouse and rat brain
- Evaluation of the brain uptake properties of [1-^C]labeled hexanoate in anesthetized cats by means of positron emission tomography
- A human friendly reporting and database system for brain PET analysis
- Evaluation of [^C]SA5845 and [^C]SA4503 for imaging of sigma receptors in tumors by animal PET
- Radiosynthesis and in vivo evaluation of ^C-labeled 1,5-diarylpyrazole derivatives for mapping cyclooxygenases
- Use of reference tissue models for quantification of histamine H_1 receptors in human brain by using positron emission tomography and [^C]doxepin
- Preclinical studies on [^C]TMSX for mapping adenosine A_ receptors by positron emission tomography
- Cerebral Ischemic Lesions Detected With Diffusion-Weighted Magnetic Resonance Imaging After Carotid Artery Stenting : Comparison of Several Anti-embolic Protection Devices
- Parkinsonism in Type I Gauchers Disease
- Development of PET radiopharmaceuticals and their clinical applications at the Positron Medical Center
- Effects of a robotic walking exercise on walking performance in community-dwelling elderly adults
- Comparison of ^F-fluoromethylcholine and 2-deoxy-D-glucose in the distribution of tumor and inflammation
- Repeat Hepatectomy for Recurrent Colorectal Metastases
- Small cell neuroendocrine carcinoma of the ampulla of Vater with foci of squamous differentiation : a case report
- Longer than 3-Year Survival Following Hepato-Ligamento-Pancreatoduodenectomy for Hilar Cholangiocarcinoma with Vascular Involvement : Report of a Case
- Preparatory hepatic resection with right hepatic vein reconstruction for paracaval liver tumor
- The Pre-Supplementary and Primary Motor Areas Generate Rhythm for Voluntary Eye Opening and Closing Movements
- Age-related changes of the [^C]CFT binding to the striatal dopamine transporters in the Fischer 344 rats : a PET study
- Age-related changes of the binding of [^3H]SA4503 to sigma_1 receptors in the rat brain
- Transfemoral Superior Ophthalmic Vein Approach Via the Facial Vein for the Treatment of Carotid-Cavernous Fistulas : Two Case Reports
- Brief screening tool for mild cognitive impairment in older Japanese : Validation of the Japanese version of the Montreal Cognitive Assessment
- DEVELOPMENTAL CHANGES OF PHOTORECEPTOR ORGANS DURING POSTEMBRYONIC DEVELOPMENT OF THE ASCIDIAN CIONA INTESTINALIS(Developmental Biology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- Improved synthesis of [^C]SA4503, [^C]MPDX and [^C]TMSX by use of [^C]methyl triflate
- Involvement of CD11b+ GR-1low cells in autoimmune disorder in MRL-Faslpr mouse
- 11C-Labeled Analogs of Indomethacin Esters and Amides for Brain Cyclooxygenase-2 Imaging: Radiosynthesis, in Vitro Evaluation and in Vivo Characteristics in Mice
- Data base and management system for clinical positron emission tomography (PET) studies
- Assessment of residual liver functional reserve after portal embolization with positron emission tomography using L-[methyl-^C] methionine and computed tomography
- METALLOTHIONEIN (MT-1, -2) DEFICIENCY INDUCED DOWN-REGULATION OF DOPAMINERGIC NEURON IN METALLOTHIONEIN-KNOCKOUT AND/OR Hg^0-EXPOSURED MICE BRAIN
- An alternative synthesis of [^C]raclopride for routine use
- Carbon-11 labeled ethionine and propionine as tumor detecting agents
- High-spatial-resolution MR Imaging of Focal Breast Masses : Interpretation Model Based on Kinetic and Morphological Parameters
- THE COLONIC NEOBLADDER : A STOMA-FREE BLADDER SUBSTITUTE AFTER RADICAL CYSTECTOMY : PRELIMINARY RESULTS IN SIX PATIENTS
- Animal tumor models for PET in drug development
- Changes in Hemodynamics After Placing Intracranial Stents
- Therapeutic Response to Pramipexole in a Patient with Multiple System Atrophy with Predominant Parkinsonism: Positron Emission Tomography and Pharmacokinetic Assessments
- Oscillopsia Associated with Dysfunction of Visual Cortex
- Changes in Hemodynamics After Placing Intracranial Stents
- 11C-PiB PET Imaging of Encephalopathy Associated with Cerebral Amyloid Angiopathy
- Direct comparison of radiation dosimetry of six PET tracers using human whole-body imaging and murine biodistribution studies