Therapeutic Response to Pramipexole in a Patient with Multiple System Atrophy with Predominant Parkinsonism: Positron Emission Tomography and Pharmacokinetic Assessments
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概要
- 論文の詳細を見る
Multiple system atrophy with predominant parkinsonism (MSA-P) usually shows poor responsiveness to dopaminergic medications. We herein describe a patient with MSA-P who exhibited a good response to pramipexole but not to an ordinary dose of L-dopa. Positron emission tomography (PET) displayed severely impaired presynaptic dopaminergic availability and relatively preserved postsynaptic D2 receptor binding capacity. The pharmacokinetic analyses demonstrated relatively low bioavailability for L-dopa and adequate plasma levels of pramipexole, even at baseline, on a stable daily dose. The PET features and pharmacokinetic differences between L-dopa and pramipexole indicate the presence of unique therapeutic responses to dopaminergic medications in the patient.
- 社団法人 日本内科学会の論文
著者
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Ishii Kenji
Positron Medical Center Tokyo Metropolitan Institute Of Gerontology
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Katayama Yasuo
Department Of Internal Medicine Divisions Of Neurology Nephrology And Rheumatology Nippon Medical Sc
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Nishiyama Yasuhiro
Department Of Applied Chemistry Osaka University
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Ueda Masayuki
Department Of Public Health Faculty Of Veterinary Medicine Hokkaido University
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Nakajima Nobuhito
Department of Neurology, Kitamurayama Public Hospital, Japan
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Nagayama Hiroshi
Department of Internal Medicine, Division of Neurology, Nephrology and Rheumatology, Nippon Medical School, Japan
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Nagayama Hiroshi
Department of Neurology, Nippon Medical School, Japan
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Nishiyama Yasuhiro
Department of Neurology, Nippon Medical School, Japan
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Katayama Yasuo
Department of Neurology, Nippon Medical School, Japan
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Ueda Masayuki
Department of Internal Medicine, Isumi Medical Center, Japan
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