The Asymmetric Dimethylarginine Level is Associated with the Predicted Stroke Risk in Japanese Women
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概要
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Aim: Asymmetric dimethylarginine(ADMA) has recently been investigated as a risk marker for cardio- and cerebrovascular diseases. However, it is not currently known whether the ADMA levels are related to the risk of stroke in Japanese women.Methods: We examined 192 Japanese women(mean age, 55±9 years, range, 40-80 years) who underwent health examinations. The ADMA level and various vascular risk factors of each subject were assessed, and the predicted 10-year stroke risk was calculated using the point-based prediction model provided by the Japan Public Health Center study.Results: In a correlation coefficient analysis, age was found to be the only factor significantly correlated with the ADMA level. A significant odds ratio (OR) for a high predicted stroke risk(10-year risk, ≥5%) was noted in the highest ADMA level tertile(6.24; 95% CI, 1.13-34.5; p=0.036) compared with the lowest tertile, after adjusting for potential confounding factors. A significant OR for a high predicted stroke risk was also found for each increment in the ADMA tertile and standard deviation(adjusted OR, 2.42; 95% CI, 1.09-5.34; p=0.029; and 2.51; 95% CI, 1.24-5.11; p=0.011, respectively).Conclusions: An elevated ADMA level is significantly associated with an increased predicted stroke risk, suggesting that measuring the ADMA level is useful for identifying Japanese women with an elevated stroke risk.
- 一般社団法人 日本動脈硬化学会の論文
著者
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Otsuka Toshiaki
Deparment Of Hygiene And Public Health Nippon Medical School
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Nishiyama Yasuhiro
Department Of Applied Chemistry Osaka University
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Abe Arata
Department of Neurological Sciences, Graduate School of Medicine, Nippon Medical School, Japan
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Ueda Masayuki
Department of Internal Medicine, Isumi Medical Center, Japan
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Muraga Kanako
Department of Neurology, Nippon Medical School Main Hospital, Japan
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Nishiyama Yasuhiro
Department of Neurological Science, Graduate School of Medicine, Nippon Medical School
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Otsuka Toshiaki
Department of Hygiene and Public Health, Graduate School of Medicine, Nippon Medical School
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KATAYAMA Yasuo
Department of Internal Medicine (Division of Neurology, Nephrology and Rheumatology), Nippon Medical School
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