A Racemization-Free Coupling Method for Peptides Having N-Methylamino Acids at the Carboxy-Termini
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概要
- 論文の詳細を見る
To search for recemization-free coupling conditions for peptides having N-alkylamino acids at the carboxy-termini, a model coupling using Boc-Phe-MeAla-OH (MeAla, N-methylalanine) and H-Phe-OBzl was studied. When benzotriazolyl-N-oxytris(dimethylamino)phosphonium hexafluorophosphate or O-(7-azabenzotriazol-1-yl)-1,1,3,3,-tetramethyluronium hexafluorophosphate was employed as a coupling reagent, no additives so far examined could sufficiently suppress the racemization of the carboxy-terminal MeAla residue. Though N-hydroxy compounds were not satisfactorily effective also in 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (WSCI)-mediated coupling, CuCl_2 could eliminate the racemization of MeAla in the coupling with WSCI even at room temperature.
- 公益社団法人日本薬学会の論文
- 1999-04-15
著者
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Miura Tomisato
弘前大学 理工学研究科物質理工学
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Mori Tetsuya
Department Of Radiology And Nuclear Medicine Hyogo Brain And Heart Center
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Mori Tomonori
(present Address)faculty Of Engineering Towa University
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Mori Tomonori
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Mori T
First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.
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Ishizuka Sou
Department Of Industrial Chemistry Faculty Of Engineering Seikei University
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Kurita K
Department Of Applied Chemistry Faculty Of Engineering Seikei University
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Kurita Keisuke
Department Of Applied Chemistry Faculty Of Engineering Seikei University
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Kurita Keisuke
Department Of Materials And Life Science Faculty Of Science And Technology Seikei University
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Nishiyama Y
Department Of Pathology And Laboratory Medicine The University Of Texas-houston Medical School
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Nishiyama Yasuhiro
Department Of Applied Chemistry Osaka University
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Tanaka Masaru
Department Of Cardiology Cardiovascular Center Osaka Red Cross Hospital
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Nishiyama Y
Department Of Natural Medicinal Chemistry Kobe Pharmaceutical University
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SAITO Shoubu
Department of Industrial Chemistry, Faculty of Engineering, Seikei University
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Saito Shoubu
Department Of Industrial Chemistry Faculty Of Engineering Seikei University
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Tanaka Masaru
Department Of Industrial Chemistry Faculty Of Engineering Seikei University
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