Effects of Alkaloids from Aconitum yesoense var. macroyesoense on Cutaneous Blood Flow in Mice
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概要
- 論文の詳細を見る
Nine alkaloid constituents in the root of Aconitum yesoense var. macroyesoense, as well as three acetylated derivatives, were examined for their peripheral vaso-activities by measuring laser-flowmetrically the cutaneous blood flow in the hind foot of mice after intravenous administration. The major constitutive delcosine (1), 14-acetyldelcosine (2) and lucidusculine (3), respectively, had little or very mild vaso-activity. Kobusine (4) and pseudokobusine (5) and three minor constituents, luciculine (6), 1-acetylluciculine (7) and dehydroluciculine (8), together exhibited a rapid increase in blood flow reaching a peak with a magnitude almost equal to that produced by hydralazine, when administered intravenously at the same dosage level of 20 mg/kg. Among them, 4 was characterized by successive reversal of the increase to a decrease in blood flow, while 7 produced a flow with a more delayed peak time. Dehydrolucidusculine (9) exhibited a transient decrease in blood flow prior to occurrence of the increase, as did papaverine. Consequently, it is assumed that the alkaloids, especially those of the C_<20>-diterpenoid type, in the root of this Aconitum plant have peripherally vaso-dilating activities to varying degrees in mice, probably due to their direct action on the cutaneous microvasculature in a similar fashion to that shown by hydralazine. The laser blood flowmetric method would be useful as an in vivo means of qualitative as well as quantitative screening of chemically modified derivatives of peripherally vasoactive agents in mice.
- 公益社団法人日本薬学会の論文
- 1997-09-15
著者
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坂東 博人
京都大学薬学部薬剤学教室
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Mori Tetsuya
Department Of Radiology And Nuclear Medicine Hyogo Brain And Heart Center
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板東 博人
京大・薬
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Mori T
First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.
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Ishizuki S
Hokkaido College Of Pharmacy
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Kawahara N
National Institute Of Health Sciences
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WADA Koji
Hokkaido College of Pharmacy
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MORI Takao
Hokkaido College of Pharmacy
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KAWAHARA Norio
Hokkaido College of Pharmacy
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ISHIZUKI Satoshi
Hokkaido College of Pharmacy
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BANDO Hideo
Hokkaido College of Pharmacy
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MURAYAMA Mituo
Research Sections, Sanwa Shoyaku Co., Ltd.,
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坂東 博人
Kyoto Univ. Kyoto Jpn
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和田 勝夫
Research Laboratories Kyoto Pharmaceutical Industries Ltd.
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Wada Katsuo
Research Laboratories Kyoto Pharmaceutical Industries Ltd.
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Murayama Mituo
Research Sections Sanwa Shoyaku Co. Ltd.
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