Effect of Oral OPC-28326, a Selective Femoral Arterial Vasodilator, on Hindlimb Subcutaneous Tissue Temperature in Conscious Dogs Under Buprenorphine Sedation
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概要
- 論文の詳細を見る
In dogs, rectal temperature was decreased to about 36°C at 2 to 2.5 h after sedation with buprenorphine (0.3 mg/body, i.m.), and hindlimb subcutaneous tissue temperature (TSC) in the thigh decreased in a similar manner. TSC in the dorsum of the foot showed a greater decrease than that in the thigh. OPC-28326 (4-(N-methyl-2-phenylethylamino)-1-(3,5-dimethyl-4-propionyl-aminobenzoyl) piperidine hydrochloride monohydrate) at doses of 0.3, 1.0 and 3.0 mg/kg, p.o. inhibited the buprenorphine-induced decrease in TSC in the dorsum dose-dependently, but had little effect on that in the thigh or rectal temperature. In conclusion, TSC in the extremities were more sensitive to core temperature and peripheral circulation.
- 社団法人 日本薬理学会の論文
- 2002-01-01
著者
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Orito Kensuke
Second Tokushima Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd
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Mori Tetsuya
Department Of Radiology And Nuclear Medicine Hyogo Brain And Heart Center
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Mori T
First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.
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Kishi M
Second Tokushima Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd
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FUJIKI HIROYUKI
Second Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co. Ltd.
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Fujiki Hiroyuki
Second Tokushima Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd
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IMAIZUMI Takashi
Second Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd
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YOSHIDA Kenji
Second Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd
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KISHI Masami
Second Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd
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MORI Toyoki
Second Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd
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Kishi Masami
Second Tokushima Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd
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Yoshida Kenji
Second Tokushima Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd
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Imaizumi Takashi
Second Tokushima Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd
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