Effects of OPC-51803, a Novel, Nonpeptide Vasopressin V_2-Receptor Agonist, on Micturition Frequency in Brattleboro and Aged Rats

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概要

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• We assessed the effects of OPC-51803 ((5R)-2-[1-(2-chloro-4-(1-pyrrolidinyl)benzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-yl]-N-isopropylacetamide), a nonpeptide vasopessin V2-receptor agonist, on micturition frequency in female homozygous Brattleboro rats (strain carries hereditary diabetes insipidus) and aged male Sprague-Dawley rats with polyuria. Female homozygous Brattleboro rats exhibited more diuresis and a larger micturition frequency over a 24-h period than did the heterozygous controls. In Brattleboro rats, an oral administration of OPC-51803 at 0.03 and 0.3 mg/kg significantly decreased urinary frequency and was accompanied by decreased urine volume. However, little effect was seen in the mean and maximal micturition volume. Aged male Sprague-Dawley rats (25-month-old) showed a significant increase in urine volume throughout a 0- to 24-h period compared with mature (6-month-old) rats. Orally administered OPC-51803 at 0.3 mg/kg decreased not only urine volume but also urinary frequency in aged rats. Furthermore, OPC-51803 prolonged the time prior to the first micturition. Therefore, OPC-51803 decreased micturition frequency in both rat species by reducing urine outflow. This suggests that the compound will be useful for treating micturition disorders that result in frequent micturition, such as that from polyuria, nocturnal polyuria, and some kinds of urinary incontinence.

• 社団法人 日本薬理学会の論文
• 2003-12-01

著者

• KAMBE Toshimi

  First Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd

• Nakamura S

  First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• NAKAMURA Shigeki

  First Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.

• HIRANO Takahiro

  First Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.

• ITOH Shuji

  First Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.

• YAMAMURA Yoshitaka

  First Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.

• MORI Toyoki

  First Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.

• KONDO Kazumi

  First Institute of New Drug Research, Otsuka Pharmaceutical Co. , Ltd.

• Mori Tetsuya

  Department Of Radiology And Nuclear Medicine Hyogo Brain And Heart Center

• Yamamura Y

  First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• Nakamura Shigeki

  First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• Hirano Takahiro

  First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• Mori T

  First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• Yamamura Yoshitaka

  First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• Itoh Shuji

  First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• Itoh Shuji

  2nd Tokushima Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• Kondo Kazumi

  Medicinal Chemistry Research Institute Otsuka Pharmaceutical Co. Ltd.

• Kambe Toshimi

  First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• Hirano Takahiro

  First Inst. Of New Drug Discovery Otsuka Pharmaceutical Co. Ltd.

• Yabuuchi Y

  First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

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